- DIMER COMPOUNDS, AND USE IN BINDING TOXIC REPEATS OF RNA
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Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are dimeric inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.
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Paragraph 0131; 0133; 0134
(2020/07/16)
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- Fullerene-Filled Liquid-Crystal Stars: A Supramolecular Click Mechanism for the Generation of Tailored Donor–Acceptor Assemblies
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Two shape-persistent star mesogens with oligo(phenylene ethenylene) arms and a phthalocyanine core—one providing free space (2) and one sterically encumbered by four fullerenes attached through spacers (3)—have been successfully synthesized. In contrast to the smaller discotic derivative 1, mesogen 2 forms a columnar liquid crystal (LC), which can only be partially aligned without π-stacking, while 3 is not an LC. Exceptionally, the 1:1 mixture of 2 and 3 forms an alignable columnar LC with strong π-stacking and quadruply helically organized fullerenes by an unprecedented click process that is similar to a ball detent mechanism. The C60 units also interconnect different columns. This is driven by nanosegregation and space-filling of the voids with fullerenes. Photophysical studies confirm the presence of a light-collecting system that generates charge-separated states in solution and in the solid state, which makes such highly organized materials attractive for the study of future photovoltaic devices.
- Lehmann, Matthias,Dechant, Moritz,Holzapfel, Marco,Schmiedel, Alexander,Lambert, Christoph
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supporting information
p. 3610 - 3615
(2019/02/09)
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- Alkoxy-Group-Functionalized UiO-66 as Highly Efficient Adsorbents for Hydrogen Chloride Removal from Aqueous Solution
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A series of alkoxy group-functionalized UiO-66 were designed for hydrogen chloride adsorption from aqueous solution, which were characterized by various methods to verify the structures and study the adsorption mechanism. A volcano-shaped change of adsorp
- Liu, Hongxu,Lan, Xiaoyu,Bai, Peng,Guo, Xianghai
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p. 286 - 295
(2019/01/04)
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- BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING SAME
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Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1 ), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.
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Paragraph 00927; 00928; 00930
(2019/06/05)
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- DIHYDROINDENE AND TETRAHYDRONAPHTHALENE COMPOUNDS
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The invention provides compounds of formula I: and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers, Alzheimer's disease, and conditions associated with demyelination.
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Paragraph 0213; 0214
(2018/08/09)
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- Photopatterning of fluorescent host-guest carriers through pore activation of metal-organic framework single crystals
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Encoded fluorescent particles are fabricated through the selective uptake of dyes in photopatterned metal-organic framework single crystals. The concept is based on spatially controlled photochemical cleavage of pore-blocking pendant groups. Because of the crystalline and porous nature of the host, this approach enables guest uptake that is tunable and can be triggered though controlled irradiation.
- Stassen,Boldog,Steuwe,De Vos,Roeffaers,Furukawa,Ameloot
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supporting information
p. 7222 - 7225
(2017/07/11)
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- AB type hydroxyl-modified polymer of a monomer and its midbody and preparation method
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The invention discloses monomers and intermediates of an AB type hydroxyl modified high polymer, and preparation methods of the monomers and the intermediates. The intermediates include methyl o-hydroxyl p-carboxyl benzoate (I) and m-hydroxyl p-methoxycarbonyl benzoyl chloride (I'). The monomers of the AB type hydroxyl modified high polymer include a monomer (IV) of AB type hydroxyl modified PPTA (Poly-p-Phenylene Terephthamide) and a monomer (VIII) of AB type hydroxyl modified PBO (Poly-p-phenylenebenzobisthiazole), wherein R1 is H, R2 is OH, or R1 is OH and R2 is OH, and R is CH3 or C2H5. Due to introduction of hydroxyl in the AB type monomer, the light resistance, the composite cohesiveness and the axial pressure resistance of a high polymer prepared from the AB type hydroxyl modified high polymer can be improved, and moreover the preparation methods of the intermediate and the monomer have the characteristics of high yield, high selectivity and industrial production accordance.
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Paragraph 0086; 0087
(2016/10/08)
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- Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group
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An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.
- Yang, Yiqing,Lin, Yun,Rao, Yu
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supporting information; experimental part
p. 2874 - 2877
(2012/07/28)
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- Gated channels in a honeycomb-like zinc-dicarboxylate-bipyridine framework with flexible alkyl ether side chains
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Covalent functionalization of 1,4-benzenedicarboxylate (bdc) with methoxyethoxy groups induces conformational freedom in this molecule. Applying these 2,5-disubstituted bdc derivatives in metal-organic framework synthesis together with 4,4′-bipyridine as coligand yields novel honeycomb-like structures. The cylindrical channels of these materials are populated with flexible groups, which act as molecular gates for guest molecules. This allows highly selective sorption of CO2 over N2 and CH 4.
- Henke, Sebastian,Fischer, Roland A.
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supporting information; experimental part
p. 2064 - 2067
(2011/04/16)
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- Photochemical activation of a metal-organic framework to reveal functionality
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Seeing the light: Two highly porous metal-organic frameworks (MOFs) were transformed using UV light to produce MOFs with hydroxy and catechol groups through an unusual postsynthetic deprotection reaction (see scheme). Copyright
- Tanabe, Kristine K.,Allen, Corinne A.,Cohen, Seth M.
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supporting information; experimental part
p. 9730 - 9733
(2011/03/17)
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- Flexibility and sorption selectivity in rigid metal-organic frameworks: The impact of ether-functionalised linkers
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The functionalisation of well-known rigid metal-organic frameworks (namely, [Zn4O(bdc)3]n, MOF-5, IRMOF-1 and [Zn 2(bdc)2(dabco)]n; bdc=1,4-benzene dicarboxylate, dabco=diazabicyclo[2.2.2]octane) with additional alkyl ether groups of the type -O-(CH2)n-O-CH3 (n = 2-4) initiates unexpected structural flexibility, as well as high sorption selectivity towards CO2 over N2 and CH4 in the porous materials. These novel materials respond to the presence/absence of guest molecules with structural transformations. We found that the chain length of the alkyl ether groups and the substitution pattern of the bdc-type linker have a major impact on structural flexibility and sorption selectivity. Remarkably, our results show that a high crystalline order of the activated material is not a prerequisite to achieve significant porosity and high sorption selectivity. Just breathe! The implementation of linkers functionalised with flexible ether groups in known, but rigid metal-organic frameworks (MOFs), yields isoreticular frameworks that exhibit unexpected responsiveness towards small molecules and high sorption selectivity for CO2 (see figure). Copyright
- Henke, Sebastian,Schmid, Rochus,Grunwaldt, Jan-Dierk,Fischer, Roland A.
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experimental part
p. 14296 - 14306
(2011/03/20)
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- Substituents on quinone methides strongly modulate formation and stability of their nucleophilic adducts
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Electronic perturbation of quinone methides (QM) greatly influences their stability and in turn alters the kinetics and product profile of QM reaction with deoxynucleosides. Consistent with the electron-deficient nature of this reactive intermediate, electron-donating substituents are stabilizing and electron-withdrawing substituents are destabilizing. For example, a dC N3-QM adduct is made stable over the course of observation (7 days) by the presence of an electron-withdrawing ester group that inhibits QM regeneration. Conversely, a related adduct with an electron-donating methyl group is very labile and regenerates its QM with a half-life of approximately 5 h. The generality of these effects is demonstrated with a series of alternative quinone methide precursors (QMP) containing a variety of substituents attached at different positions with respect to the exocyclic methylene. The rates of nucleophilic addition to substituted QMs measured by laser flash photolysis similarly span 5 orders of magnitude with electron-rich species reacting most slowly and electron-deficient species reacting most quickly. The reversibility of QM reaction can now be predictably adjusted for any desired application.
- Weinert, Emily E.,Dondi, Ruggero,Colloredo-Melz, Stefano,Frankenfield, Kristen N.,Mitchell, Charles H.,Freccero, Mauro,Rokita, Steven E.
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p. 11940 - 11947
(2007/10/03)
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- Isolation of bright blue fluorescent substances from sonochemical hydroxylation of methyl p-cyanobenzoate
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Sonochemical hydroxylation of methyl p-cyanobenzoate (1a) in water gave a bright blue fluorescence, which are mainly ascribed to three new fluorescent compounds, 3-hydroxy, 2,3- and 2,5-dihydroxy derivatives of 1a. Other benzenes substituted with electron-withdrawing groups also gave similar fluorescence from their hydroxylated derivatives. Among the fluorescence substances, methyl 2,5-dihydroxybenzoate was supposed to be applicable for a fluorescent chemosensor.
- Yamada, Sachiko,Hokari, Hajime,Akasaka, Shinji,Iwamura, Michiko
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p. 197 - 198
(2007/10/03)
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- Selective and one-pot formation of phenols by anodic oxidation
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Direct monohydroxylation of benzene and substituted benzenes was successfully performed by anodic oxidation to form the corresponding phenol derivatives in good yields. The anodic oxidation was generally carried out in a mixed solvent of trifluoroacetic acid and dichloromethane containing triethylamine using a divided cell equipped with a platinum plate as the anode, a carbon rod as the cathode. Benzene derivatives having electron withdrawing groups were suitable for the present electrochemical oxidation. It was clarified that aryltrifluoroacetates were formed as the initial products from the reaction of the radical cations, generated by one electron transfer from the substrates, with trifluoroacetic acid, followed by hydrolysis during work-up to give the corresponding phenols.
- Fujimoto, Kazuo,Tokuda, Yuichiro,Maekawa, Hirofumi,Matsubara, Yoshiharu,Mizuno, Takumi,Nishiguchi, Ikuzo
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p. 3889 - 3896
(2007/10/03)
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- Nonproteinogenic Amino Acids, IV. - EPC Synthesis of L-(+)-Forphenicine
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Enantiomerically pure L-(+)-forphenicine (12) is synthesized starting from purchasable 3-methoxybenzaldehyde (1) by the use of (4S,5S)-(+)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane (2) as a chiral auxiliary and prussic acid. 12 is identical with the natural product which has been isolated from the culture broth of an Actinomyces species and which is known to be a potent inhibitor of alkaline phosphatase.
- Weinges, Klaus,Reinel, Ute,Maurer, Wolfgang,Gaessler, Norbert
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p. 833 - 838
(2007/10/02)
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