6342-72-9Relevant academic research and scientific papers
DIMER COMPOUNDS, AND USE IN BINDING TOXIC REPEATS OF RNA
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, (2020/07/16)
Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are dimeric inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.
Fullerene-Filled Liquid-Crystal Stars: A Supramolecular Click Mechanism for the Generation of Tailored Donor–Acceptor Assemblies
Lehmann, Matthias,Dechant, Moritz,Holzapfel, Marco,Schmiedel, Alexander,Lambert, Christoph
, p. 3610 - 3615 (2019/02/09)
Two shape-persistent star mesogens with oligo(phenylene ethenylene) arms and a phthalocyanine core—one providing free space (2) and one sterically encumbered by four fullerenes attached through spacers (3)—have been successfully synthesized. In contrast to the smaller discotic derivative 1, mesogen 2 forms a columnar liquid crystal (LC), which can only be partially aligned without π-stacking, while 3 is not an LC. Exceptionally, the 1:1 mixture of 2 and 3 forms an alignable columnar LC with strong π-stacking and quadruply helically organized fullerenes by an unprecedented click process that is similar to a ball detent mechanism. The C60 units also interconnect different columns. This is driven by nanosegregation and space-filling of the voids with fullerenes. Photophysical studies confirm the presence of a light-collecting system that generates charge-separated states in solution and in the solid state, which makes such highly organized materials attractive for the study of future photovoltaic devices.
BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING SAME
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, (2019/06/05)
Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1 ), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.
Alkoxy-Group-Functionalized UiO-66 as Highly Efficient Adsorbents for Hydrogen Chloride Removal from Aqueous Solution
Liu, Hongxu,Lan, Xiaoyu,Bai, Peng,Guo, Xianghai
, p. 286 - 295 (2019/01/04)
A series of alkoxy group-functionalized UiO-66 were designed for hydrogen chloride adsorption from aqueous solution, which were characterized by various methods to verify the structures and study the adsorption mechanism. A volcano-shaped change of adsorp
DIHYDROINDENE AND TETRAHYDRONAPHTHALENE COMPOUNDS
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Paragraph 0213; 0214, (2018/08/09)
The invention provides compounds of formula I: and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers, Alzheimer's disease, and conditions associated with demyelination.
Photopatterning of fluorescent host-guest carriers through pore activation of metal-organic framework single crystals
Stassen,Boldog,Steuwe,De Vos,Roeffaers,Furukawa,Ameloot
supporting information, p. 7222 - 7225 (2017/07/11)
Encoded fluorescent particles are fabricated through the selective uptake of dyes in photopatterned metal-organic framework single crystals. The concept is based on spatially controlled photochemical cleavage of pore-blocking pendant groups. Because of the crystalline and porous nature of the host, this approach enables guest uptake that is tunable and can be triggered though controlled irradiation.
AB type hydroxyl-modified polymer of a monomer and its midbody and preparation method
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Paragraph 0086; 0087, (2016/10/08)
The invention discloses monomers and intermediates of an AB type hydroxyl modified high polymer, and preparation methods of the monomers and the intermediates. The intermediates include methyl o-hydroxyl p-carboxyl benzoate (I) and m-hydroxyl p-methoxycarbonyl benzoyl chloride (I'). The monomers of the AB type hydroxyl modified high polymer include a monomer (IV) of AB type hydroxyl modified PPTA (Poly-p-Phenylene Terephthamide) and a monomer (VIII) of AB type hydroxyl modified PBO (Poly-p-phenylenebenzobisthiazole), wherein R1 is H, R2 is OH, or R1 is OH and R2 is OH, and R is CH3 or C2H5. Due to introduction of hydroxyl in the AB type monomer, the light resistance, the composite cohesiveness and the axial pressure resistance of a high polymer prepared from the AB type hydroxyl modified high polymer can be improved, and moreover the preparation methods of the intermediate and the monomer have the characteristics of high yield, high selectivity and industrial production accordance.
Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group
Yang, Yiqing,Lin, Yun,Rao, Yu
supporting information; experimental part, p. 2874 - 2877 (2012/07/28)
An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.
Gated channels in a honeycomb-like zinc-dicarboxylate-bipyridine framework with flexible alkyl ether side chains
Henke, Sebastian,Fischer, Roland A.
, p. 2064 - 2067 (2011/04/16)
Covalent functionalization of 1,4-benzenedicarboxylate (bdc) with methoxyethoxy groups induces conformational freedom in this molecule. Applying these 2,5-disubstituted bdc derivatives in metal-organic framework synthesis together with 4,4′-bipyridine as coligand yields novel honeycomb-like structures. The cylindrical channels of these materials are populated with flexible groups, which act as molecular gates for guest molecules. This allows highly selective sorption of CO2 over N2 and CH 4.
Flexibility and sorption selectivity in rigid metal-organic frameworks: The impact of ether-functionalised linkers
Henke, Sebastian,Schmid, Rochus,Grunwaldt, Jan-Dierk,Fischer, Roland A.
, p. 14296 - 14306 (2011/03/20)
The functionalisation of well-known rigid metal-organic frameworks (namely, [Zn4O(bdc)3]n, MOF-5, IRMOF-1 and [Zn 2(bdc)2(dabco)]n; bdc=1,4-benzene dicarboxylate, dabco=diazabicyclo[2.2.2]octane) with additional alkyl ether groups of the type -O-(CH2)n-O-CH3 (n = 2-4) initiates unexpected structural flexibility, as well as high sorption selectivity towards CO2 over N2 and CH4 in the porous materials. These novel materials respond to the presence/absence of guest molecules with structural transformations. We found that the chain length of the alkyl ether groups and the substitution pattern of the bdc-type linker have a major impact on structural flexibility and sorption selectivity. Remarkably, our results show that a high crystalline order of the activated material is not a prerequisite to achieve significant porosity and high sorption selectivity. Just breathe! The implementation of linkers functionalised with flexible ether groups in known, but rigid metal-organic frameworks (MOFs), yields isoreticular frameworks that exhibit unexpected responsiveness towards small molecules and high sorption selectivity for CO2 (see figure). Copyright
