- SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF
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The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.
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Page/Page column 194-195
(2018/04/27)
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- HETEROTRICYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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The present invention relates to novel compounds of Formula (I), wherein wherein X1, X2, Y, Z1, Z2, Z3, M and (A)m are defined as in Formula (I); invention compounds are modulators of metab
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Page/Page column 31
(2010/08/04)
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- Synthesis and structural study of tetrahydroindazolones
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Multinuclear magnetic resonance spectroscopy allowed us to characterize four 1(2),5,6,7-tetrahydro-4H-indazol-4-one derivatives (1-4) and establish the most stable tautomer in each case. The crystal structure of 6,6-dimethyl-1(2),5,6,7-tetrahydro-4H-indaz
- Claramunt, Rosa M.,López, Concepción,Pérez-Medina, Carlos,Pinilla, Elena,Torres, M. Rosario,Elguero, José
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p. 11704 - 11713
(2007/10/03)
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- SYNTHESIS OF ANGULAR BENZODIPYRAZOLES AND RELATED SYSTEMS
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A series of benzodipyrazoles was prepared from cyclohexane-1,3-dione.Several related systems with different central rings were also prepared.In addition, benzodipyrazoles were synthesized from 1,4-cyclohexanedione monoethylene
- Peet, Norton P.,LeTourneau, Michael E.
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- Dipyrazoles and their use as bronchodilators
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A group of variously methyl-substituted[1,2-c:3,4-c']dipyrazoles, cyclohepta[1,2-c:3,4-c']dipyrazoles, and cyclopenta[1,2-c:3,4-c']dipyrazoles useful as bronchodilators are described herein. The compounds are prepared by reacting a 1,3-diketone with hydra
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- Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodilators
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The present invention is directed to a group of methylated tetrahydro cyclohepta[1,2-c:4,3-c']dipyrazoles and benzo[1,2-c:4,3-c']dipyrazoles useful as bronchodilators. The compounds are prepared by the reaction of an appropriate hydrazine with an appropri
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