- Preparation method for 2-methoxy-N-(2-nitro-5-phenylthio) phenylacetamide
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The invention discloses a preparation method for 2-methoxy-N-(2-nitro-5-phenylthio) phenylacetamide. The preparation method comprises the following steps: in a non-polar organic solvent, under catalysis of an acid binding agent, 2-nitro-5-phenylthio-aniline and methoxyacetic acid are added, and have a chlorination reaction with thionyl chloride under reflux; after the reaction ends, excess thionylchloride is decomposed by water, standing is performed for layering; the solvent is concentrated, a solvent with poor dissolvability is added for cooling crystallization, and suction filtration and drying are performed to obtain the 2-methoxy-N-(2-nitro-5-phenylthio) phenylacetamide. The preparation method adopts a one-pot method, and uses the thionyl chloride to replace phosphorus trichloride, so that the product purity reaches 99.8% or more, and the yield reaches 93.5% or more. The method has the advantages of being simple to operate, environmental-friendly, easy to industrially produce andthe like.
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Paragraph 0028-0040
(2020/12/08)
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- Preparation method of 2-amino-5-phenylthio-(2-methoxy)acetanilide
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The invention belongs to the technical field of organic synthesis and particularly relates to a preparation method of 2-amino-5-phenylthio-(2-methoxy)acetanilide. According to the method, 2-nitro-5-(phenylthio)aniline is prepared from 2-nitro-5-mercaptoaniline and benzene halide and then subjected to a reaction with methyl methoxyacetate, 2-nitro-5-phenylthio-(2-methoxy)acetanilide is generated and subjected to catalytic hydrogenation reduction finally, and the target product is obtained. The preparation method has good reaction selectivity, and the obtained target product is high in purity and yield; use of high-toxicity materials is avoided, requirements for equipment and operation conditions are reduced, and safety and stability of the preparation method are improved; doses of the reaction materials are optimized, and excess benzene halide and methyl methoxyacetate can be recycled after being recovered simply; little solid waste is produced, waste treatment cost is reduced greatly,and the requirement for environmental protection is met.
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- Febantel, a new broad-spectrum anthelminthic
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N {2 [2,3 Bis (methoxycarbonyl) guanidino] 5 (phenylthio) phenyl } 2 methoxyacetamide (febantel, Rintal) is a new compound which is highly active against various species of nematodes and cestodes in mice, rats, dogs, sheep and cattle. In sheep and cattle a single oral dose of 5 mg/kg resulted in an almost complete elimination of larval and adult intestinal nematodes as well as Dictyocaulus. The compound was well tolerated by all animals tested.
- Wollweber,Koelling,Widdig,Thomas,Schulz,Muermann
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p. 2193 - 2195
(2007/10/13)
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