- Donepezil myristyloxymethyl ether or its pharmaceutically acceptable salt
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The present invention relates to a novel donepezil myristyloxymethyl ether or a pharmaceutically acceptable salt thereof, and a sustained-release pharmaceutical composition containing the same as a main component. Donepezil myristyloxymethyl ether of the
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Paragraph 0109-0111; 0117-0119
(2019/10/08)
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- Electrochemical methoxymethylation of alcohols-a new, green and safe approach for the preparation of MOM ethers and other acetals
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A new, green, safe, cost-effective and highly efficient electrochemical approach for the methoxymethylation of alcohols and phenols was successfully developed. The methodology was also applied to the synthesis of substituted acetals.
- Luo, Xiya,Ma, Xiaofeng,Lebreux, Frédéric,Markó, István E.,Lam, Kevin
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supporting information
p. 9969 - 9972
(2018/09/11)
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- COMPOUND; TAUTOMER AND GEOMETRIC ISOMER THEREOF; SALT OF SAID COMPOUND, TAUTOMER, OR GEOMETRIC ISOMER; METHOD FOR MANUFACTURING SAID COMPOUND, TAUTOMER, ISOMER, OR SALT; ANTIMICROBIAL AGENT; AND ANTI-INFECTIVE DRUG
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A compound represented by any one of General Formulas (1) to (5), a tautomer or geometric isomer thereof, or a salt thereof.
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Paragraph 0151-0154; 0158
(2015/09/23)
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- Chromium(VI) oxide oxidation of non-ethoxylated and ethoxylated alcohols for determination by electrospray ionization mass spectrometry
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A new derivatization procedure to increase the sensitivity of electrospray ionization mass spectrometry (ESI-MS) to non-ethoxylated and ethoxylated alcohols was investigated. The analytes were oxidized with chromium(VI) oxide and the resulting carboxylic and ethoxy-carboxylic acids were isolated by extraction with ethyl acetate; the extracts were alkalinized and infused into the ESI-MS system working in the negative-ion mode. The yields of the combined oxidation-extraction were ca. 100% for non-ethoxylated fatty alcohols dissolved in acetone and they decreased moderately in samples containing increasing amounts of water (e.g., a 75% yield was obtained with 50% water). Ethoxylated alcohols with more than two ethylene oxide units resulted in yields of ca. 60%. Low limits of detection (LODs) were obtained when the procedure was applied to the analysis of body- care products and cosmetics containing fatty alcohols, e.g., in a varicose-vein cream, the LODs were 25 μ cetyl alcohol and 7.5 μ stearyl alcohol (detected as palmitic acid and stearic acid, respectively) per gram of sample. High molecular mass alcohols were also detected in seawater after pre- concentration by solid-phase extraction. Thus, the proposed method is particularly valuable for use in industrial samples having complex matrices and in environmental samples and it is competitive with other methods for the analysis of trace amounts of fatty alcohols.
- Beneito-Cambra, Miriam,Bernabe-Zafon, Virginia,Simo-Alfonso, Ernesto F.,Ramis-Ramos, Guillermo
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experimental part
p. 2093 - 2100
(2011/11/06)
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- Asymmetric synthesis of secondary alcohols from primary alcohols via intramolecular carbenoid C-H insertion catalyzed by rhodium(II) 3-phenylcholestane-2-carboxylate
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Chiral secondary alcohols may be prepared from primary alcohols via asymmetric C-H insertion reactions of α′-alkoxy-α-diazoketones catalyzed by rhodium(II) (2R,3K)-3-phenylcholestane-2-carboxylate.
- Hwang, Cheol Hee,Chong, You Hoon,Song, Sue Yeon,Kwak, Hyo Shin,Lee, Eun
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p. 816 - 817
(2007/10/03)
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