636992-54-6

Basic information

• Product Name: 3-AMino-5-broMo-2-cyano-benzofuran
• Synonyms: 3-AMino-5-broMo-2-cyano-benzofuran;3-Amino-5-bromobenzofuran-2-carbonitrile
• CAS NO: 636992-54-6
• Molecular Formula: C9H5BrN2O
• Molecular Weight: 237.0528
• Mol File: 636992-54-6.mol

Chemical Properties

• Boiling Point: 402.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.78±0.1 g/cm3(Predicted)
• PKA: -1.97±0.10(Predicted)
• CAS DataBase Reference: 3-AMino-5-broMo-2-cyano-benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMino-5-broMo-2-cyano-benzofuran(636992-54-6)
• EPA Substance Registry System: 3-AMino-5-broMo-2-cyano-benzofuran(636992-54-6)

Safety Data

• Hazardous Substances Data: 636992-54-6(Hazardous Substances Data)

Upstream product

• 40530-18-5 5-bromo-2-hydroxybenzonitrile 
• 107-14-2 chloroacetonitrile 
• 636992-52-4 5-bromo-2-cyanomethoxy-benzonitrile 

Relevant articles and documents

INHIBITORS OF HIV REPLICATION

Compounds of formula (I): wherein R1, R2, A1, A2, A3, A4, X and Y are as defined herein, are useful as inhibitors of HIV replication.

Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity

Novel 3-acetoacetylaminobenzo[b]furan derivatives having a modified triene system at the 3-position were synthesized starting with 3-aminobenzo[b]furans. The enol isomers, 3-[(3-hydroxybul-2-enonyl)amino]benzo[b]furans (1), of the 3-acetoacetylaminobenzo[b]furans were obtained as stable isomers owing to formation of a hydrogen bonding between the enol hydroxyl group and the amidocarbonyl group. The planarity of the C-2 substituent through the C-3 side chain suggested the existence of a modified conjugational triene system in the enol compound. Cysteinyl leukotriene 1 and 2 receptor antagonistic activities for these compounds were evaluated. 2-(4-Cyanobenzoyl or ethoxycarbonyl)-3-[(2-cyano-3-hydroxybut-2-enonyl)amino]benzo[e]furans (15g, 15o, 15u) were moderately active.

Preparation of 3-acetoacetylaminobenzo[b]furan derivatives with cysteinyl leukotriene receptor 2 antagonistic activity.

Novel 3-acetoacetylaminobenzo[b]furan derivatives with a modified triene system at the 3-position were prepared through acylation of the 3-aminobenzo[b]furans with 5-methylisoxazole-4-carboxylic acid chloride followed by basic cleavage of the isoxazole ring and several of these compounds showed moderate cysteinyl leukotriene receptor 2 antagonistic activity.