637348-81-3

Basic information

• Product Name: 3-Bromo-2-hydroxy-5-iodopyridine
• Synonyms: 3-Bromo-2-hydroxy-5-iodopyridine;3-broMo-5-iodopyridin-2-ol;3-BroMo-5-iodo-2-hydroxypyridine;3-bromo-5-iodo-2(1H)-Pyridinone
• CAS NO: 637348-81-3
• Molecular Formula: C₅H₃BrINO
• Molecular Weight: 299.9
• Mol File: 637348-81-3.mol

Chemical Properties

• Boiling Point: 308.0±42.0 °C(Predicted)
• Appearance: /
• Density: 2.55±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.66±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-2-hydroxy-5-iodopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-hydroxy-5-iodopyridine(637348-81-3)
• EPA Substance Registry System: 3-Bromo-2-hydroxy-5-iodopyridine(637348-81-3)

Safety Data

• Hazardous Substances Data: 637348-81-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-2-hydroxy-5-iodopyridine is used as a key intermediate in the synthesis of various pharmaceuticals for its potential biological activity and contribution to the development of new drugs. It aids in the creation of compounds with specific therapeutic properties, enhancing drug discovery efforts.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Bromo-2-hydroxy-5-iodopyridine is utilized as a precursor in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals that improve crop protection and yield.
Used in Materials Science:
3-Bromo-2-hydroxy-5-iodopyridine is employed as a component in the preparation of advanced materials, leveraging its unique structural features to create materials with specialized properties for various applications in science and industry.
Used as a Reagent in Organic Synthesis:
3-Bromo-2-hydroxy-5-iodopyridine serves as a reagent in organic synthesis, facilitating the preparation of other organic compounds through diverse synthetic routes, thus expanding the scope of chemical research and development.

Upstream product

• 13472-81-6 3,5-dibromo-2-hydroxypyridine 
• 13466-43-8 3-bromo-pyridin-2-ol 

Downstream Products

• 937183-75-0 tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate 
• 937183-84-1 (E)-[5-bromo-6-(2-hydroxyethoxy)pyridin-3-yl]-2-(4-hydroxyphenyl)-ethylene 
• 937183-73-8 (E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-hydroxyphenyl)-ethylene 
• 937183-81-8 (E)-4-(2-(5-bromo-6-(2-hydroxyethoxy)pyridin-3-yl)vinyl)phenyl acetate 
• 937183-80-7 (E)-[5-bromo-6-(2-hydroxyethoxy)pyridin-3-yl]-2-(4-methylaminophenyl)-ethylene 
• 937183-79-4 (E)-[5-bromo-6-(2-hydroxyethoxy)pyridin-3-yl]-2-(4-dimethylaminophenyl)-ethylene 
• 937183-69-2 (E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl acetate 
• 937183-68-1 tert-butyl (E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate 
• 937183-67-0 (E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-methylaminophenyl)-ethylene 
• 937183-66-9 (E)-(5-bromo-6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)-2-(4-dimethylaminophenyl)-ethylene 

Relevant articles and documents

HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY

Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X, X, and Xare N, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I foranddiagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

8-FLUOROPHTHALAZIN-1(2H)-ONE COMPOUNDS

8-Fluorophthalazin-1(2h)-one compounds of Formula II where one or two of X1, X2, and X3 are N, are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula II for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Novel styrylpyridines as probes for SPECT imaging of amyloid plaques

We report a series of radioiodinated styrylpyridines as single photon emission computed tomography probes for imaging Aβ plaques in the brain of patients with Alzheimer's disease (AD). In vitro binding showed that all of the styrylpyridines displayed very good binding affinities in postmortem AD brain homogenates (Ki = 3.6 to 15.5 nM). No-carrier-added samples of 13a, 13b, 16a, 16b, and 16e (radioiodinated with 125I) were successfully prepared. The in vivo biodistribution in normal mice, at 2 min after injection, showed excellent initial brain penetrations (4.03, 6.22, 5.43, and 8.04% dose/g for [125I]13a, 13b, 16a, and 16b, respectively). Furthermore, in vitro autoradiography of AD brain sections showed that the high binding signal was specifically due to the presence of Aβ plaques. Taken together, these results strongly suggest that these styrylpyridines are useful for imaging Aβ plaques in the living human brain.

STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES

This invention relates to a method of imaging amyloid deposits and to styrylpyridine compounds, and methods of making radiolabeled styrylpyridine compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making

Efficient regioselective preparation of monobromo and bromoiodo hydroxy pyridines from dibromoderivatives via bromine-lithium exchange

Annular dibromination of hydroxypyridines with NBS in acetonitrile followed by bromine-lithium exchange with RLi and subsequent trapping with H2O or I2 afforded monobromo and bromoiodo derivatives in a completely regioselective way. Iodination of bromo hydroxypyridines with NIS is totally regioselective.