937183-75-0

Basic information

• Product Name: tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate
• Synonyms: tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate
• CAS NO: 937183-75-0
• Molecular Weight: 586.442
• Mol File: 937183-75-0.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate(937183-75-0)
• EPA Substance Registry System: tert-butyl (E)-4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridin-3-yl)vinyl)phenyl(methyl)carbamate(937183-75-0)

Safety Data

• Hazardous Substances Data: 937183-75-0(Hazardous Substances Data)

Upstream product

• 57295-14-4 tert-butyl 4-vinylphenylcarbamate 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 637348-81-3 3-bromo-5-iodopyridin-2-ol 
• 77544-68-4 8-tosyloxy-3,6-dioxaoctanol 
• 1520-21-4 4-vinyl benzylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 373-45-5 2-(2-(2-fluoroethoxy)ethoxy)ethanol 
• 937183-64-7 3-bromo-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-5-iodopyridine 
• 937183-61-4 4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene 
• 13466-43-8 3-bromo-pyridin-2-ol 
• 937183-68-1 tert-butyl (E)-4-(2-(5-bromo-6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate 

Relevant articles and documents

Novel styrylpyridines as probes for SPECT imaging of amyloid plaques

We report a series of radioiodinated styrylpyridines as single photon emission computed tomography probes for imaging Aβ plaques in the brain of patients with Alzheimer's disease (AD). In vitro binding showed that all of the styrylpyridines displayed very good binding affinities in postmortem AD brain homogenates (Ki = 3.6 to 15.5 nM). No-carrier-added samples of 13a, 13b, 16a, 16b, and 16e (radioiodinated with 125I) were successfully prepared. The in vivo biodistribution in normal mice, at 2 min after injection, showed excellent initial brain penetrations (4.03, 6.22, 5.43, and 8.04% dose/g for [125I]13a, 13b, 16a, and 16b, respectively). Furthermore, in vitro autoradiography of AD brain sections showed that the high binding signal was specifically due to the presence of Aβ plaques. Taken together, these results strongly suggest that these styrylpyridines are useful for imaging Aβ plaques in the living human brain.

STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES

This invention relates to a method of imaging amyloid deposits and to styrylpyridine compounds, and methods of making radiolabeled styrylpyridine compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making