637753-82-3Relevant articles and documents
Carboxylated aurone derivatives as potent inhibitors of xanthine oxidase
Muzychka, Oksana V.,Kobzar, Oleksandr L.,Popova, Antonina V.,Frasinyuk, Mykhaylo S.,Vovk, Andriy I.
, p. 3606 - 3613 (2017/06/13)
Xanthine oxidase is a potential target for treatment of hyperuricemia and gout. In this study, a number of A- and B-ring carboxylated aurone derivatives were synthesized and evaluated for their ability to inhibit xanthine oxidase in vitro. According to the results obtained, two different ranges of inhibitory activity were observed. The aurones with carboxylic acid group at the 4′-position of B-ring were found to be potent inhibitors of the enzyme with IC50 values in the low micromolar range. The effects of these compounds were about 50 fold higher than of A-ring modified aurones with carboxymethoxy group at the 6-position. The binding modes of the carboxylated aurones in the active site of xanthine oxidase were explained using molecular docking calculations.
Synthesis of Flavonoid Derivatives of Cytisine. 5. Aminomethylation of 6-Hydroxyaurones
Popova,Bondarenko,Podobii,Frasinyuk,Vinogradova
, p. 708 - 713 (2017/10/06)
Aminomethylation of 6-hydroxy- and 6-hydroxy-7-methylaurones by the alkaloid cytisine was studied. It was shown that the aminomethylation of the 6-hydroxyaurones occurred at the 7-position of the benzofuran ring and at the 5-position if the 7-position was occupied.
