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6272-26-0

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6272-26-0 Usage

Description

6-Hydroxy-2,3-dihydrobenzo[b]furan-3-one is an organic compound characterized by its faint yellow to brown powder appearance. It is a derivative of benzo[b]furan, a type of heterocyclic compound, and features a hydroxyl group at the 6th position and a carbonyl group at the 3rd position. 6-Hydroxy-2,3-dihydrobenzo[b]furan-3-one is known for its potential applications in various industries, particularly as a pharmaceutical intermediate.

Uses

Used in Pharmaceutical Industry:
6-Hydroxy-2,3-dihydrobenzo[b]furan-3-one is used as a pharmaceutical intermediate for the synthesis of various drugs and medicinal compounds. Its unique chemical structure allows it to serve as a building block in the development of new pharmaceuticals, potentially contributing to the creation of novel treatments for a range of health conditions.
As a chemical intermediate, 6-Hydroxy-2,3-dihydrobenzo[b]furan-3-one can be further modified or reacted with other compounds to produce a variety of pharmaceutically active substances. Its versatility in chemical reactions makes it a valuable asset in the field of drug discovery and development.

Check Digit Verification of cas no

The CAS Registry Mumber 6272-26-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,7 and 2 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6272-26:
(6*6)+(5*2)+(4*7)+(3*2)+(2*2)+(1*6)=90
90 % 10 = 0
So 6272-26-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H6O3/c9-5-1-2-6-7(10)4-11-8(6)3-5/h1-3,9H,4H2

6272-26-0 Well-known Company Product Price

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  • (Code)Product description
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  • Detail
  • Alfa Aesar

  • (L10951)  6-Hydroxy-2,3-dihydrobenzo[b]furan-3-one, 97%   

  • 6272-26-0

  • 250mg

  • 291.0CNY

  • Detail
  • Alfa Aesar

  • (L10951)  6-Hydroxy-2,3-dihydrobenzo[b]furan-3-one, 97%   

  • 6272-26-0

  • 1g

  • 500.0CNY

  • Detail
  • Alfa Aesar

  • (L10951)  6-Hydroxy-2,3-dihydrobenzo[b]furan-3-one, 97%   

  • 6272-26-0

  • 5g

  • 1810.0CNY

  • Detail
  • Aldrich

  • (630039)  6-Hydroxy-3-coumaranone  97%

  • 6272-26-0

  • 630039-1G

  • 469.17CNY

  • Detail
  • Aldrich

  • (630039)  6-Hydroxy-3-coumaranone  97%

  • 6272-26-0

  • 630039-5G

  • 1,208.61CNY

  • Detail

6272-26-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Hydroxy-2,3-dihydrobenzo[b]furan-3-one

1.2 Other means of identification

Product number -
Other names 6-hydroxy-1-benzofuran-3-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6272-26-0 SDS

6272-26-0Relevant articles and documents

Flavone inspired discovery of benzylidenebenzofuran-3(2H)-ones (aurones) as potent inhibitors of human protein kinase CK2

Bdzhola, V. G.,Bilokin, Y. V.,Borysenko, I. P.,Lukashov, S. S.,Protopopov, M. V.,Prykhod'ko, A. O.,Starosyla, S. A.,Vdovin, V. S.,Yarmoluk, S. M.

supporting information, (2020/07/21)

In this work, we describe the design, synthesis and SAR studies of 2-benzylidenebenzofuran-3-ones (aurones), a new family of potent inhibitors of CK2. A series of aurones have been synthesized. These compounds are structurally related to the synthetic flavones and showed nanomolar activities towards CK2. Biochemical tests revealed that 20 newly synthesized compounds inhibited CK2 with IC50 values in the nanomolar range. Further property-based optimization of aurones was performed, yielding a series of CK2 inhibitors with enhanced lipophilic efficiency. The most potent compound 12m (BFO13) has CLipE = 4.94 (CLogP = 3.5; IC50 = 3.6 nM) commensurable with the best known inhibitors of CK2.

PD-1/PD-L1 small-molecule inhibitor and preparation method and application thereof

-

Paragraph 0221; 0226; 0227; 0228, (2019/05/08)

The invention discloses a PD-1/PD-L1 small-molecule inhibitor and a preparation method and application thereof. Specifically, the invention discloses a compound with the structure shown in the formulaL, a stereoisomer or a tautomer thereof, or pharmaceutically acceptable salts or hydrates or solvates thereof, and please see the specification for specific definitions. The compound has excellent effects for restraining PD-1/PD-L1. Please see the specification for the formula.

Aurones as new porcine pancreatic α-amylase inhibitors

Roshanzamir, Khashayar,Kashani-Amin, Elaheh,Ebrahim-Habibi, Azadeh,Navidpour, Latifeh

, p. 333 - 340 (2019/06/20)

Background: Aurones, (Z)-2-benzylidenebenzofuran-3-one derivatives, are naturally-occurring structural isomers of flavones, with promising pharmacological potential. Methods: In this study, the structural requirements for the inhibition of porcine pancreatic α-amylase by hydroxylated or methoxylated aurone derivatives were investigated by assessing their in vitro biological activities against porcine pancreatic α-amylase. Results: The structure-activity relationship of these inhibitors based on both in vitro and in silico findings showed that the hydrogen bonds between the OH groups of the A or B ring of (Z)-benzylidenebenzofuran-3-one derivatives and the catalytic residues of the binding site are crucial for their inhibitory activities. Conclusion: It seems that the OH groups in aurones inhibit α-amylase in a manner similar to that of OH groups in flavones and flavonols.

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