637756-31-1Relevant articles and documents
Synthesis of tritium labelled mecillinam
Frederiksen, Soren Melsing,Grue-Sorensen, Gunnar
, p. 773 - 779 (2007/10/03)
The potent β-lactam antibiotic mecillinam has successfully been labelled with tritium. 2,3,4,7-Tetrahydro-1H-azepin-1-carbaldehyde was formed in a ring-closing metathesis reaction and then condensed with trimethylsilyl protected penicillanic acid to give dehydro-mecillinam. Pd/C catalysed tritiation then gave [3H2]-mecillinam (6-β (([3,4-3H2]hexahydro-1H-azepin-1-yl)methyleneamino) penicillanic acid) with a radiochemical purity of 96% and a specific activity of 24Ci/mmol. Copyright