639091-78-4

Basic information

• Product Name: (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: RARECHEM AL BW 2482;(4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER;2-(Boc-amino)-4-(aminomethyl)pyridine;tert-butyl N-[4-(aMinoMethyl)pyridin-2-yl]carbaMate
• CAS NO: 639091-78-4
• Molecular Formula: C₁₁H₁₇N₃O₂
• Molecular Weight: 223.27
• Mol File: 639091-78-4.mol

Chemical Properties

• Melting Point: 131-132 °C
• Boiling Point: 321.9°C at 760 mmHg
• Flash Point: 148.5°C
• Appearance: /
• Density: 1.164g/cm³
• Vapor Pressure: 0.000289mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.42±0.70(Predicted)
• CAS DataBase Reference: (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER(639091-78-4)
• EPA Substance Registry System: (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER(639091-78-4)

Safety Data

• Hazardous Substances Data: 639091-78-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a building block for the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents.
Used in Agricultural Industry:
In the agricultural sector, (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a reagent in organic chemical reactions, aiding in the production of agrochemicals and other related products.
Used in Organic Chemical Reactions:
(4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a reagent in various organic chemical reactions, facilitating the synthesis of a wide range of organic compounds for different applications.

InChI:InChI=1/C11H17N3O2/c1-11(2,3)16-10(15)14-9-6-8(7-12)4-5-13-9/h4-6H,7,12H2,1-3H3,(H,13,14,15)

Upstream product

• 639091-77-3 tert-butyl {4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]pyridin-2-yl}carbamate 
• 304873-62-9 (4-hydroxymethylpyridin-2-yl)carbamic acid tert-butyl ester 
• 639091-75-1 methyl 2-[(tert-butoxycarbonyl)amino]isonicotinate 
• 639091-76-2 {2-[(tert-butoxycarbonyl)amino]pyridin-4-yl}methyl methanesulfonate 
• 6313-54-8 2-chloroisonicotinic acid, 
• 13362-28-2 2-aminoisonicotinic acid 
• 856897-86-4 (4-azidomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: A potent and orally bioavailable NCX inhibitor

Ca2+ overload in myocardial cells is responsible for arrhythmia. Sodium-calcium exchanger (NCX) inhibitors are more effective than sodium-hydrogen exchanger (NHE) inhibitors with regard to modulation of Ca 2+ overload, because NCX inhibitors can directly inhibit the influx of Ca2+ into cells. NCX is an attractive target for the treatment of heart failure and ischemia-reperfusion. We have designed and synthesized a series of N-(2-aminopyridin-4-ylmethyl)nicotinamide derivatives, based on compound 5. We have discovered a novel NCX inhibitor (23h) with an IC 50 value of 0.12 μM against reverse NCX. The inhibitory activities of our NCX inhibitors against cytochrome P450 were also evaluated. The effects on heart failure and the pharmacokinetic profile of compound 23h are discussed.

NEW PYRIDIN-2-ONE COMPOUNDS USEFUL AS INHIBITORS OF THROMBIN

There is provided a compound of formula I, wherein the dashed line, R1, R2, R3a, R3b, A, D, E, G and L have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is beneficial (e.g. conditions, such as thrombo-embolisms, where inhibition of thrombin is required or desired, and/or conditions where anticoagulant therapy is indicated).

NEW 5,6-DIHYDROPYRIN-2-ONE COMPOUNDS USEFUL AS INHIBITORS OF THROMBIN

There is provided a compound of formula (I) wherein R1, R2a, R2b, R3a, R3b, R4, R5, R6, A, G and L have meanings given in the description, which compounds are useful a