(4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 639091-78-4
• Molecular Formula: C11H17 N3 O2
• Molecular Weight: 223.275
• Hs Code.: 2933399090
• Mol file: 639091-78-4.mol

Synonyms:Carbamicacid, [4-(aminomethyl)-2-pyridinyl]-, 1,1-dimethylethyl ester (9CI); (4-Aminomethylpyridin-2-yl)carbamicacid tert-butyl ester

Chemical Property of (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0.000289mmHg at 25°C
• Melting Point: 131-132 °C
• Boiling Point: 321.9oC at 760 mmHg
• PKA: 12.42±0.70(Predicted)
• Flash Point: 148.5oC
• PSA: 77.24000
• Density: 1.164g/cm3
• LogP: 2.66060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

(4-Aminomethylpyridin-2-yl)carbamic acidtert-butyl ester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

There total 7 articles about (4-AMINOMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl {4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]pyridin-2-yl}carbamate (639091-77-3) → tert-butyl [4-(aminomethyl)pyridin-2-yl]carbamate (639091-78-4)

Guidance literature:

With hydrazine hydrate; In methanol; chloroform; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2005.03.052

Reference yield: 85.0%

(4-azidomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester (856897-86-4) → tert-butyl [4-(aminomethyl)pyridin-2-yl]carbamate (639091-78-4)

Guidance literature:

With sodium tetrahydroborate; water; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

(4-hydroxymethylpyridin-2-yl)carbamic acid tert-butyl ester (304873-62-9) → tert-butyl [4-(aminomethyl)pyridin-2-yl]carbamate (639091-78-4)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C

2: 11.24 g / dimethylformamide / 50 °C

3: 100 percent / H₂NNH₂*H₂O / methanol; CHCl₃ / 24 h / 20 °C

With hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.03.052

upstream raw materials:

tert-butyl {4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]pyridin-2-yl}carbamate

(4-hydroxymethylpyridin-2-yl)carbamic acid tert-butyl ester

methyl 2-[(tert-butoxycarbonyl)amino]isonicotinate

{2-[(tert-butoxycarbonyl)amino]pyridin-4-yl}methyl methanesulfonate