63979-60-2Relevant articles and documents
One-step coupling of tris(hydroxymethyl)aminomethane to aliphatic and aromatic carboxylic acids
Villanueva,Hernandez,Chang,Heagy
, p. 1435 - 1438 (2000)
A convenient and general method was established to append tri-, hexa-, and nonadentate ligands about an aromatic or aliphatic core. This approach allows a variety of commercially available carboxylic acids to be transformed to their N-tris(hydroxymethyl)m
The effect of molecular shape and microphase segregation on the formation of liquid crystal phases in poly-ols
West, Jonathan J.,Bonsergent, Guenola,Mackenzie, Grahame,Ewing, David F.,Goodby, John W.,Benvegnu, Thierry,Plusquellec, Daniel,Bachir, Sabrina,Bault, Phillipe,Douillet, Olivier,Gode, Paul,Goethals, Gerard,Martin, Patrick,Villa, Pierre
, p. 23 - 44 (2001)
In this article we examine the effect of molecular shape on the formation of thermotropic phases of alkyl-substituted poly-ols. The relationship between the cross-sectional area of the hydrophilic head group with respect to the that of the hydrophilic tails determines the type of mesophase formed. The results obtained are similar to those found for the formation of lyotropic phases.
Binding of a Fatty Acid-Functionalized Anderson-Type Polyoxometalate to Human Serum Albumin
Bijelic, Aleksandar,Dobrov, Anatolie,Roller, Alexander,Rompel, Annette
, p. 5243 - 5246 (2020)
The Anderson-type hexamolybdoaluminate functionalized with lauric acid (LA), (TBA)3[Al(OH)3Mo6O18{(OCH2)3CNHCOC11H23}]·9H2O (TBA-AlMo6-LA, where TBA = tetrabutylammonium), was prepared via two synthetic routes and characterized by thermogravimetric and elemental analyses, mass spectrometry, IR and 1H NMR spectroscopy, and powder and single-crystal X-ray diffraction. The interaction of TBA-AlMo6-LA with human serum albumin (HSA) was investigated via fluorescence and circular dichroism spectroscopy. The results revealed that TBA-AlMo6-LA binds strongly to HSA (63% quenching at an HSA/TBA-AlMo6-LA ratio of 1:1), exhibiting static quenching. In contrast to TBA-AlMo6-LA, the nonfunctionalized polyoxometalate, Na3(H2O)6[Al(OH)6Mo6O18]·2H2O (AlMo6), showed weak binding toward HSA (22% quenching at a HSA/AlMo6 ratio of 1:25). HSA binding was confirmed by X-ray structure analysis of the HSA-Myr-AlMo6-LA complex (Myr = myristate). These results provide a promising lead for the design of novel polyoxometalate-based hybrids that are able to exploit HSA as a delivery vehicle to improve their pharmacokinetics and bioactivity.
Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane
Megarajan, Sengan,Subramaniyan, Siva Bala,Muthuswamy, Sureshan,Anthony, Savarimuthu Philip,Arunachalam, Jothi,Moon, Dohyun,Veerappan, Anbazhagan
, p. 32823 - 32831 (2018/10/08)
Herein, we reported the supramolecular organization of N-acyltris(hydroxymethyl)aminomethane (NATM) in the solid state as well as in aqueous solution. Single crystal X-ray diffraction revealed that NATM adopts a fully interdigitized structure. The thermodynamic parameters associated with thermotropic phase behaviour of NATM was determined by differential scanning calorimetry. The molecular packing and phase state of the NATM analyzed by laurdan and prodan fluorescence supports the formation of an interdigitized phase in aqueous solution. The potential application of the self-assembled NATM vesicles was demonstrated through entrapping model drug, Rhodamine B.
Safe and efficient in vitro and in vivo gene delivery: Tripodal cationic lipids with programmed biodegradability
Unciti-Broceta, Asier,Moggio, Loredana,Dhaliwal, Kevin,Pidgeon, Laura,Finlayson, Keith,Haslett, Chris,Bradley, Mark
supporting information; experimental part, p. 2154 - 2158 (2011/10/09)
The therapeutic use of nucleic acids has long been heralded as a panacea of medicinal opportunity, a vision enhanced by the introduction of RNA interference technology. The Achilles heel of such an approach is the in vivo delivery of the desired nucleic acid into cells, a practice that lacks selectivity, safety and/or efficiency. Herein we report the safe and efficacious in vitro and in vivo delivery of nucleic acids using tripodal biodegradable cationic lipids. Toxicity reduction and transfection potency of these novel amphiphiles were addressed by designing the compounds to undergo complete intracellular degradation thereby enhancing cargo release while minimising toxicity and potential tissue accumulation. Compounds demonstrated high-efficiency in transfecting DNA into cells both in vitro and in vivo with no signs of toxicity, thus potentially offering a safer alternative to viral transfection for gene therapy application. The Royal Society of Chemistry.
CATIONIC LIPIDS
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Page/Page column 27, (2009/05/28)
This invention relates to cationic lipids. More particularly the invention relates to biodegradable cationic lipids having a plurality of cationic headgroups and one or more lipophilic tail groups. The lipids are of utility in various applications, and in particular in permitting transfection of molecules, and in particular DNA and RNA, into cells. As such the lipids have specific utility in the field of gene therapy as well as other applications such as delivery of small molecules into cells, detergents, and metal ion complexation for medical or industrial applications.
