The enantioselective total synthesis of aspergillide C, a member of a novel class of 14-membered macrolides isolated from the marine-derived fungus Aspergillus ostianus strain 01F313, has been accomplished employing a highly diastereoselective intramolecu
Total synthesis of (R)-(+)-goniothalamin and (R)-(+)-goniothalamin oxide: first application of the sulfoxide-modified Julia olefination in total synthesis
A short and efficient synthesis of (R)-(+)-goniothalamin 1 and (R)-(+)-goniothalamin oxide 2 is described. During this approach, the sulfoxide-modified Julia olefination was used as a key step to connect aldehyde 5 to sulfoxide 6. The desired styryl-containing adduct is obtained in good yield and with excellent E/Z selectivity.
Pospí?il, Ji?í,Markó, István E.
p. 5933 - 5937
(2007/10/03)
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