64043-31-8Relevant articles and documents
Syntheses of the opioid substructures 1,2,3,4,5,6-hexahydro-2,6-methano-3- benzazocine and 2,3,4,5-tetrahydro-1,5-methano-1H-2-benzazepine
Coe, Jotham W.,Brooks, Paige R.,Vetelino, Michael G.,Bashore, Crystal G.,Bianco, Krista,Flick, Andrew C.
, p. 953 - 954 (2011/03/18)
Concise syntheses of 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine (12) and 2,3,4,5-tetrahydro-1,5-methano-1H-2-benzazepine (18) are described and involve an intramolecular Friedel-Crafts alkylation and an intramolecular Heck cyclization as their respec
1,4-Bis(arylsulfonyl)-1,2,3,4-tetrahydropyridines in synthesis. Intramolecular alkylation reactions and stereoselective synthesis of anti-2,6-disubstituted piperidines
Craig, Donald,McCague, Raymond,Potter, Gerard A.,Williams, Meredith R. V.
, p. 58 - 60 (2007/10/03)
1,4-Bis(arylsulfonyl)-1,2,3,4-tetrahydropyridines 1 having R1 containing aromatic groups undergo intramolecular electrophilic aromatic substitution reactions to give benzo-fused bicyclo[3.3.1] systems with chemoselectivities which depend on the nature of the acidic reagent used. Cationic hydrogenation of the C-5-C-6 double bond in substrates 1 substituted at C-6 provides an entry to anti-2,6-disubstituted piperidines upon desulfonylation.