64165-35-1 Usage
Uses
Used in Pharmaceutical and Agrochemical Industries:
5-chloroquinolin-6-ol is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals for its potential to contribute to the development of new drugs and pesticides. Its unique chemical structure allows for the creation of compounds with specific therapeutic or pesticidal properties.
Used in Dye and Pigment Production:
In the dye and pigment industry, 5-chloroquinolin-6-ol is utilized for the production of dyes and pigments due to its color-producing capabilities. Its chemical structure enables the creation of a wide range of colors, making it a valuable component in the formulation of various colorants.
Used in Medicinal Research and Development:
5-chloroquinolin-6-ol is used as a compound of interest in medicinal research and development, particularly for its antimicrobial and antimalarial properties. Its potential to combat infections and diseases has attracted the attention of researchers, who are exploring its therapeutic applications and possible integration into new treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 64165-35-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,1,6 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 64165-35:
(7*6)+(6*4)+(5*1)+(4*6)+(3*5)+(2*3)+(1*5)=121
121 % 10 = 1
So 64165-35-1 is a valid CAS Registry Number.
64165-35-1Relevant articles and documents
Selective biochlorination of hydroxyquinolines by a flavin-dependent halogenase
Xu, Fuchao,Merkley, Amanda,Yu, Dayu,Zhan, Jixun
supporting information, p. 5262 - 5265 (2016/11/09)
Rdc2 is a flavin-dependent halogenase from Pochonia chlamydosporia. Through the introduction of a His6-tag to both the N- and C-termini, the isolation yield of Rdc2 from Escherichia coli using Ni-NTA affinity chromatography was increased by three-fold. In vitro reaction of Rdc2 and a flavin reductase (Fre) with seven different hydroxyquinolines revealed that 3-hydroxyquinoline (3), 5-hydroxyquinoline (5), 6-hydroxyquinoline (6), and 7-hydroxyquinoline (7) can be specifically halogenated. These products were prepared by incubating the corresponding substrates with IPTG-induced E. coli BL21(DE3)/Rdc2. They were respectively characterized as 3-hydroxy-4-chloroquinoline (3a), 5-hydroxy-6-chloroquinoline (5a), 5-chloro-6-hydroxyquinoline (6a), and 7-hydroxy-8-chloroquinoline (7a) by NMR and MS analyses. This work represents the first enzymatic preparation of chlorohydroxyquinolines and provides a ‘green’ method to synthesize this group of medicinally important compounds.
