- Synthesis process of high-purity oxiconazole nitrate
-
The invention relates to a synthesis process of high-purity oxiconazole nitrate, and belongs to the technical field of pharmacy, thesynthesis process comprises the following steps: 1, stirring and mixing 2-chloro-1-(2, 4-dichlorophenyl) ethanone, imidazole and absolute methanol, carrying out reflux reaction, adding hydrogen peroxide, ammonia monohydrate and a modified catalyst, continuously reacting, and purifying, and obtaining (Z)-2 '-(1H-imidazole-1-yl)-2, 4-dichloroacetophenone oxime with relatively high purity; 2, (Z)-2 '-(1H-imidazole-1-yl)-2, 4-dichloroacetophenone oxime and 2, 4-dichlorobenzyl chloride are subjected to a substitution reaction, high-purity oxiconazole nitrate is obtained through suction filtration, washing, drying and recrystallization, the traditional synthesis process is analyzed, the synthesis method and the mode of adding a modified catalyst are changed, generation of impurities is reduced, the purity of products in production links is improved, the synthesis steps are reduced, the synthesis route is shortened and the production efficiency is improved.
- -
-
Paragraph 0047-0048; 0050; 0055-0056; 0058; 0062-0064; ...
(2021/09/15)
-
- Imidazolyl-oxime ethers having anti-mycotic and bactericidal activity
-
Imidazolyl oxime ethers (I) are disclosed which contain an aromatic or heteroaromatic grouping linked to the carbon atom of the oxime ether, the oxime being etherified by a variety of groups; aliphatic, aromatic, heteroaromatic, cycloaliphatic and aliphatic substituted by aromatic, heteroaromatic or cycloaliphatic groups. The compounds are obtained from the corresponding ketones by reaction with O-substituted hydroxylamines or by reaction of metal oximates with halides of the required etherifying group. The said products (I) possess antimycotic and bactericidal activity.
- -
-
-