Novel Lavendamycin Analogues as Potent HIV-Reverse Transcriptase Inhibitors: Synthesis and Evaluation of Anti-Reverse Transcriptase Activity of Amide and Ester Analogues of Lavendamycin
Novel lavendamycins including two water soluble derivatives were synthesized via short and efficient methods. Pictet-Spengler condensation of 7-N-acylamino-2-formylquinoline-5,8-diones with tryptophans produced lavendamycin esters or amides 11-17. Lavenda
Behforouz, Mohammad,Cai, Wen,Stocksdale, Mark G.,Lucas, Jennifer S.,Jung, Joo Yong,Briere, Daniel,Wang, Aiqin,Katen, Kevin S.,Behforouz, Nancy C.
Lavendamycin analogues and methods of synthesizing and using lavendamycin analogues
Lavendamycin analogues, methods for their synthesis, and methods for their use in the treatment of diseases such as cancer and HIV infection are described.
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(2010/10/20)
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