- Asymmetric Total Synthesis of ent-Pyripyropene A
-
An asymmetric total synthesis of ent-pyripyropene A was achieved by a convergent synthetic route. We used our originally developed TiIII-catalyzed radical cyclization to construct an AB-ring portion that consisted of a trans-decalin skeleton wi
- Fuse, Shinichiro,Ikebe, Ayako,Oosumi, Kazuya,Karasawa, Tomoya,Matsumura, Keisuke,Izumikawa, Miho,Johmoto, Kohei,Uekusa, Hidehiro,Shin-Ya, Kazuo,Doi, Takayuki,Takahashi, Takashi
-
-
Read Online
- Synthesis and Reaction of 6-Substituted 3-Methoxycarbonyl-4-methylthio-2H-pyran-2-one Derivatives
-
Reaction of aryl and styryl methyl ketones 1a-m with dimethyl bis(methylthio)methylenemalonate (2) in the presence of potassium hydroxide in dimethyl sulfoxide gave the corresponding methyl 6-aryl- and 6-styryl-4-methylthio-2-oxo-2H-pyran-3-carboxylates 3
- Tominaga, Yoshinori,Ushirogochi, Atsuyuki,Matsuda, Yoshiro
-
p. 1557 - 1567
(2007/10/02)
-
- SYNTHESIS OF ANIBINE USING KETENE DITHIOACETAL
-
Synthesis of anibine using 3-acetylpyridine and dimethyl bis(methylthio)methylenemalonate is described.KEYWORDS - anibine; ketene dithioacetal; 3-acetylpyridine; dimethyl bis(methylthio)methylenemalonate; Aniba rosaeodora Duke
- Tominaga, Yoshinori,Matsuda, Yoshiro,Kobayashi, Goro
-
p. 1665 - 1666
(2007/10/02)
-
- Use of β-Ketocarboxylic Acids for Syntheses of 6-Substituted 4-Hydroxy-2-pyrones and Acyclic β-Diketones
-
β-Ketocarboxylic acids including β-ketoglutaric acid half-esters were cyclized by treating them with 1,1'-carbonyl-diimidazole to give 6-substituted 3-acyl-4-hydroxy-2-pyrones in good yields. 5-Aryl-3,5-dioxo-1-pentanoic acid and monomethyl malonate gave 6-aryl-4-hydroxy-2-pyrone and dimethyl β-ketoglutarate, respectively, on similar treatment.Anibin, one of the Aniba alkaloids, was synthesized from 5-(3-pyridyl)-4-hydroxy-2-pyrone.In addition, it was confirmed that reaction of magnesium β-ketocarboxylate with acylimidazolide gave the corresponding acyclic β-diketone in excellent yield.Keywords - β-ketocarboxilic acid; biogenetic-type synthesis; 4-hydroxy-2-pyrone; β-polyketide; β-ketoglutaric acid; dehydroacetic acid; anibin; Aniba alkaloid; 3-acyl-4-hydroxy-2-pyrone; β-diketone.
- Ohta, Shunsaku,Tsujimura, Atsuhiko,Okamoto, Masao
-
p. 2762 - 2768
(2007/10/02)
-