643-91-4

Upstream product

• 186581-53-3 diazomethane 
• 80601-69-0 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one 
• 92118-47-3 methyl 4-methoxy-6-(3-pyridyl)-2-oxo-2H-pyran-3-carboxylate 
• 121675-37-4 (Z)-3-Methoxy-5-oxo-5-pyridin-3-yl-pent-2-enoic acid ethyl ester 
• 350-03-8 methyl-3-pyridylketone 
• 92118-46-2 methyl 4-methylsulfanyl-2-oxo-6-pyrid-3-yl-2H-pyran-3-carboxylate 
• 59-67-6 nicotinic acid 
• 3594-37-4 nicotinoylacetone 
• 343947-60-4 3,5-dioxo-5-[3]pyridyl-valeric acid 
• 59846-45-6 nicotinoyl imidazolide 
• 36740-09-7 α-(3-pyridyl)-α-(4-morpholino)acetonitrile 
• 35471-25-1 ethyl (E)-4-bromo-3-methoxy-2-butenoate 
• 121675-33-0 ethyl (E)-δ-cyano-δ-(3'-pyridyl)-β-methoxy-δ-(4-morpholino)pent-2-enoate 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

Asymmetric Total Synthesis of ent-Pyripyropene A

An asymmetric total synthesis of ent-pyripyropene A was achieved by a convergent synthetic route. We used our originally developed TiIII-catalyzed radical cyclization to construct an AB-ring portion that consisted of a trans-decalin skeleton wi

Synthesis and Reaction of 6-Substituted 3-Methoxycarbonyl-4-methylthio-2H-pyran-2-one Derivatives

Reaction of aryl and styryl methyl ketones 1a-m with dimethyl bis(methylthio)methylenemalonate (2) in the presence of potassium hydroxide in dimethyl sulfoxide gave the corresponding methyl 6-aryl- and 6-styryl-4-methylthio-2-oxo-2H-pyran-3-carboxylates 3

SYNTHESIS OF ANIBINE USING KETENE DITHIOACETAL

Synthesis of anibine using 3-acetylpyridine and dimethyl bis(methylthio)methylenemalonate is described.KEYWORDS - anibine; ketene dithioacetal; 3-acetylpyridine; dimethyl bis(methylthio)methylenemalonate; Aniba rosaeodora Duke

Use of β-Ketocarboxylic Acids for Syntheses of 6-Substituted 4-Hydroxy-2-pyrones and Acyclic β-Diketones

β-Ketocarboxylic acids including β-ketoglutaric acid half-esters were cyclized by treating them with 1,1'-carbonyl-diimidazole to give 6-substituted 3-acyl-4-hydroxy-2-pyrones in good yields. 5-Aryl-3,5-dioxo-1-pentanoic acid and monomethyl malonate gave 6-aryl-4-hydroxy-2-pyrone and dimethyl β-ketoglutarate, respectively, on similar treatment.Anibin, one of the Aniba alkaloids, was synthesized from 5-(3-pyridyl)-4-hydroxy-2-pyrone.In addition, it was confirmed that reaction of magnesium β-ketocarboxylate with acylimidazolide gave the corresponding acyclic β-diketone in excellent yield.Keywords - β-ketocarboxilic acid; biogenetic-type synthesis; 4-hydroxy-2-pyrone; β-polyketide; β-ketoglutaric acid; dehydroacetic acid; anibin; Aniba alkaloid; 3-acyl-4-hydroxy-2-pyrone; β-diketone.