- 1-substituted benzoyl-4-fatty acyl semicarbazide derivative, preparation method and application thereof as antibacterial agent
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The invention belongs to the technical field of antibacterial agents, and relates to a 1-substituted benzoyl-4-fatty acyl semicarbazide derivative, a preparation method and application thereof as an antibacterial agent. The compound is shown in a formula
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Paragraph 0108; 0109; 0111; 0211; 0214
(2018/09/14)
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- Synthesis and anticonvulsant activity evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones
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A series of 4-butyl-5-(4-alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones (6a-6u) was designed and synthesized. The anticonvulsant effects and neurotoxicity of the compounds were evaluated with maximal electroshock test and rotarod test. Among the synthetic compounds, 4-butyl-5-(4-(2-fluorinebenzyl)phenyl)-2H-1,2,4- triazole-3 (4H)-one (6k) was the most potent with ED50 value of 27.4 mg/kg and protective index (PI = TD50/ED50) value of 12.0. Besides the anti-MES efficacy, the potency of compound 6k against seizures induced by pentylenetetrazole (PTZ), 3-mercaptopropionic acid (3-MP), and bicuculline (BIC) was also established, which suggested that the mechanisms of action including enhancing of GABAergic activity might be involved in its anticonvulsant activity.
- Zhu, Zi-Shi,Wang, Shi-Ben,Deng, Xian-Qing,Liu, Da-Chuan,Quan, Zhe-Shan
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p. 628 - 635
(2014/05/20)
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- Synthesis and gelation behavior of 4′-propyl-1,1′- bi(cyclohexyl)-4-one 4-alkoxybenzoylhydrazone
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A series of new alkoxybenzoylhydrazones of 4′-propyl-1,1′- bi(cyclohexyl)-4-one were prepared as novel low molecular weight organogelators (LMOGs). Their gelation behaviors in 10 solvents were tested. Some of the compounds could form stable gels in bulk o
- Li, Juan,Chen, Pei,Chen, Xinbing,An, Zhongwei,Li, Yan
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scheme or table
p. 1329 - 1330
(2011/02/17)
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- Synthesis and mesomorphic properties of azo compounds derived from phenyl- and thienyl-1,3,4-thiadiazole
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The synthesis and mesomorphic behaviour of new series of liquid crystals containing 1,3,4-thiadiazole and thiophene rings with azo central bond are reported (series 5a and 5b). All compounds of series 5a exhibit enantiotropic nematic mesophase and the hig
- Parra,Villouta,Vera,Belmar,Zú?iga,Zunza
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p. 1533 - 1538
(2007/10/03)
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