644981-80-6

Basic information

• Product Name: 1-Boc-4-(4-fluorophenyl)-4-piperidineacetic acid
• Synonyms: 1-Boc-4-(4-fluorophenyl)-4-piperidineacetic acid
• CAS NO: 644981-80-6
• Molecular Formula: C₁₈H₂₄FNO₄
• Molecular Weight: 337.3858632
• Mol File: 644981-80-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Boc-4-(4-fluorophenyl)-4-piperidineacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-(4-fluorophenyl)-4-piperidineacetic acid(644981-80-6)
• EPA Substance Registry System: 1-Boc-4-(4-fluorophenyl)-4-piperidineacetic acid(644981-80-6)

Safety Data

• Hazardous Substances Data: 644981-80-6(Hazardous Substances Data)

Usage

Structure

Contains a piperidine ring and a carboxylic acid functional group

Functional Groups

Piperidine ring, carboxylic acid, and Boc (tert-butoxycarbonyl) protecting group

Derivative

A derivative of piperidine

Stability

Increased stability due to the presence of the Boc protecting group

Selectivity

Allows for selective reactions to occur

Applications

Used as a building block in organic synthesis for the preparation of various pharmaceutical compounds

Potential Applications

Drug development and medicinal chemistry

Biological Activity

Can be used to synthesize biologically active compounds for the treatment of various diseases

Upstream product

• 644981-79-3 4-[(1-cyano-1-ethoxycarbonyl)-methyl]-4-(4-fluorophenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 644982-86-5 1-piperidinecarboxylic acid, 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(4-fluorophenyl)-1,1-dimethyl ester 

Downstream Products

• 644982-48-9 1,1-dimethylethyl 4-{2-[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]-2-oxoethyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate 
• 644982-31-0 4-({[1-(S)-1-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 644982-33-2 4-({[1-(3,5-dibromo-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 644982-34-3 4-({[1-(3,5-dibromo-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (enantiomer 2) 
• 644982-29-6 4-{[(3,5-dibromobenzyl)methylcarbamoyl]methyl}-4-(4-fluorophenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 644982-36-5 4-{[1-(3,5-dichloro-phenyl)-ethylcarbamoyl]-methyl}-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 644982-51-4 4-({[1-(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 644982-49-0 1,1-dimethylethyl 4-(2-{[1-(3,5-dibromophenyl)-1-methylethyl]amino}-2-oxoethyl)-4-(4-fluorophenyl)-1-piperidinecarboxylate 
• 852880-39-8 1,1-dimethylethyl 4-(4-fluorophenyl)-4-[2-(methyloxy)-2-oxoethyl]-1-piperidinecarboxylate 

Relevant articles and documents

BETA-LACTAMS FOR TREATMENT OF CNS DISORDERS

The present invention relates to novel compounds of formula (I) wherein ---- represents a single or a double bond; R represents a radical selected from formulae i), ii), iii) and iv) in which R1 is halogen, cyano, C1-4 alkyl, C1

CHEMICAL COMPOUNDS

The present invention relates to cyclic amine derivatives of formula(I) (I)whereinR represents halogen, C1-4 alkyl, cyano, C1-4 alkoxy, trifluoromethyl or trifluoromethoxy;R1 represents hydrogen, halogen, C3-7cycloalkyl, hydroxy, nitro, cyano or C1-4 alkyl optionally substituted by halogen, cyano or C1-4 alkoxy;R2 represents hydrogen or C1-4 alkyl;R3 and R4 independently represent hydrogen, cyano, C1-4 alkyl or R3 together with R4 represents C3-7 cycloalkyl;R5 represents trifluoromethyl, S(O)t C 1-4 alkyl, C1-4 alkyl, C1-4 alkoxy, trifluoromethoxy, halogen or cyano;R6 represents hydrogen or (CH2)rR7;R7 represents hydrogen, C3-7 cycloalkyl, NH(C1-4alkylOC1-4alkoxy), NH(C1-4alkyl), N(C1-4alkyl)2, OC(O)NR9R8, NR8C(O)R9 or C(O)NR9R8;R9 and R8 independently represent hydrogen, C1-4 alkyl or C3-7 cycloalkyl; m represents zero or an integer from 1 to 4;n represents 1 or 2;p is zero or an integer from 1 to 3;q is an integer from 1 to 3;r is an integer from 1 to 4;t is 0, 1 or 2;provided that when m is 0, p is 2, q, r and n represent 1, R1, R2,R3, R4, R5 and R7 are hydrogen and R is chlorine, R5 is not iodine; and pharmaceutically acceptable salts and solvates thereof; process for their preparation and their use in the treatment of conditions mediated by tackykinins and/or by selective inhibition of serotonin reuptake transporter protein.