644982-48-9

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[2-[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]-2-oxoethyl]-4-( 4-fluorophenyl)-, 1,1-dimethylethyl ester
• CAS NO: 644982-48-9
• Molecular Formula: C28H31F7N2O3
• Molecular Weight: 576.555
• Mol File: 644982-48-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[2-[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]-2-oxoethyl]-4-( 4-fluorophenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[2-[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]-2-oxoethyl]-4-( 4-fluorophenyl)-, 1,1-dimethylethyl ester(644982-48-9)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[2-[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]-2-oxoethyl]-4-( 4-fluorophenyl)-, 1,1-dimethylethyl ester(644982-48-9)

Safety Data

• Hazardous Substances Data: 644982-48-9(Hazardous Substances Data)

Upstream product

• 644981-80-6 [1-{[(1,1-dimethylethyl)-oxy]-carbonyl}-4-(4-fluorophenyl)-4-piperidinyl]-acetic acid 
• 159820-24-3 {[3,5-bis(trifluoromethyl)phenyl]methyl}methylamine 

Relevant articles and documents

CHEMICAL COMPOUNDS

The present invention relates to cyclic amine derivatives of formula(I) (I)whereinR represents halogen, C1-4 alkyl, cyano, C1-4 alkoxy, trifluoromethyl or trifluoromethoxy;R1 represents hydrogen, halogen, C3-7cycloalkyl, hydroxy, nitro, cyano or C1-4 alkyl optionally substituted by halogen, cyano or C1-4 alkoxy;R2 represents hydrogen or C1-4 alkyl;R3 and R4 independently represent hydrogen, cyano, C1-4 alkyl or R3 together with R4 represents C3-7 cycloalkyl;R5 represents trifluoromethyl, S(O)t C 1-4 alkyl, C1-4 alkyl, C1-4 alkoxy, trifluoromethoxy, halogen or cyano;R6 represents hydrogen or (CH2)rR7;R7 represents hydrogen, C3-7 cycloalkyl, NH(C1-4alkylOC1-4alkoxy), NH(C1-4alkyl), N(C1-4alkyl)2, OC(O)NR9R8, NR8C(O)R9 or C(O)NR9R8;R9 and R8 independently represent hydrogen, C1-4 alkyl or C3-7 cycloalkyl; m represents zero or an integer from 1 to 4;n represents 1 or 2;p is zero or an integer from 1 to 3;q is an integer from 1 to 3;r is an integer from 1 to 4;t is 0, 1 or 2;provided that when m is 0, p is 2, q, r and n represent 1, R1, R2,R3, R4, R5 and R7 are hydrogen and R is chlorine, R5 is not iodine; and pharmaceutically acceptable salts and solvates thereof; process for their preparation and their use in the treatment of conditions mediated by tackykinins and/or by selective inhibition of serotonin reuptake transporter protein.