Practical synthesis of 4H-pyrido[1, 2-a]pyrimidin-4-ones using ethylene glycol as a promoting solvent
A simple and useful protocol leading to different 4H-pyrido[1, 2-a] pyrimidin-4-ones have been established by cyclization of various 2-amino pyridines with β-oxo ester or alkynoate. The use of ethylene glycol was demonstrated to facilitate this condensati
Hussain, Mustafa,Liu, Jianhui
supporting information
(2020/08/13)
Silver-catalyzed highly efficient synthesis of pyrido[1,2-a]pyrimidin-4-ones from 2-aminopyridines and alkynoates
Pyrimidinone is one of the important nitrogen containing heterocycles due to their wide range of bioactivities. An efficient silver-catalyzed intermolecular cyclization of 2-aminopyridines with various alkynoates has been developed. 2-Substituted 4H-pyrido[1,2-a]pyrimidin-4-ones containing a wide range of functional groups are synthesized in the standard conditions. This transformation is conducted under convenient conditions and affords products in good yields.
Chen, Zhengwang,Wen, Yuelu,Ding, Hao,Luo, Guotian,Ye, Min,Liu, Liangxian,Xue, Jun
supporting information
p. 13 - 16
(2016/12/23)
Solvent-free synthesis of 4H-Pyrido[1,2-a]pyrimidin-4-ones catalyzed by BiCl3: A green route to a privileged backbone
An extensive array of 4H-pyrido[1,2-a]pyrimidin-4-ones have been synthesized from commercially available 2-aminopyridines and β-oxo esters with excellent yields under solvent-free conditions. The reaction, catalyzed by cheap and nontoxic BiCl3,
Roslan, Irwan I.,Lim, Qiu-Xuan,Han, Aijuan,Chuah, Gaik-Khuan,Jaenicke, Stephan
supporting information
p. 2351 - 2355
(2015/04/22)
Synthesis of some substituted pyrido[1,2-a]pyrimidin-4-ones and 1,8-naphthyridines
The substituted 4H-pyrido[1,2-a]pyrimidin-4-ones (I) were obtained by the condensation of substituted 2-aminopyridines with β-ketocarboxylic esters in PPA. Some of the derivatives I were transformed into the corresponding 1,8-naphthyridines II and III.
Ferrarini,Mori,Livi,et al.
p. 1053 - 1057
(2007/10/02)
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