64500-18-1Relevant academic research and scientific papers
Practical synthesis of 4H-pyrido[1, 2-a]pyrimidin-4-ones using ethylene glycol as a promoting solvent
Hussain, Mustafa,Liu, Jianhui
supporting information, (2020/08/13)
A simple and useful protocol leading to different 4H-pyrido[1, 2-a] pyrimidin-4-ones have been established by cyclization of various 2-amino pyridines with β-oxo ester or alkynoate. The use of ethylene glycol was demonstrated to facilitate this condensati
Silver-catalyzed highly efficient synthesis of pyrido[1,2-a]pyrimidin-4-ones from 2-aminopyridines and alkynoates
Chen, Zhengwang,Wen, Yuelu,Ding, Hao,Luo, Guotian,Ye, Min,Liu, Liangxian,Xue, Jun
supporting information, p. 13 - 16 (2016/12/23)
Pyrimidinone is one of the important nitrogen containing heterocycles due to their wide range of bioactivities. An efficient silver-catalyzed intermolecular cyclization of 2-aminopyridines with various alkynoates has been developed. 2-Substituted 4H-pyrido[1,2-a]pyrimidin-4-ones containing a wide range of functional groups are synthesized in the standard conditions. This transformation is conducted under convenient conditions and affords products in good yields.
Solvent-free synthesis of 4H-Pyrido[1,2-a]pyrimidin-4-ones catalyzed by BiCl3: A green route to a privileged backbone
Roslan, Irwan I.,Lim, Qiu-Xuan,Han, Aijuan,Chuah, Gaik-Khuan,Jaenicke, Stephan
supporting information, p. 2351 - 2355 (2015/04/22)
An extensive array of 4H-pyrido[1,2-a]pyrimidin-4-ones have been synthesized from commercially available 2-aminopyridines and β-oxo esters with excellent yields under solvent-free conditions. The reaction, catalyzed by cheap and nontoxic BiCl3,
Synthesis of some substituted pyrido[1,2-a]pyrimidin-4-ones and 1,8-naphthyridines
Ferrarini,Mori,Livi,et al.
, p. 1053 - 1057 (2007/10/02)
The substituted 4H-pyrido[1,2-a]pyrimidin-4-ones (I) were obtained by the condensation of substituted 2-aminopyridines with β-ketocarboxylic esters in PPA. Some of the derivatives I were transformed into the corresponding 1,8-naphthyridines II and III.
