Novel Approach to the Synthesis of Isotopomeric MonoalkylPhosphates. The Stereospecific One-pot Conversion of (Rp)-Thymidine 3'-(Nitrophenyl)-phosphorothioate into (Rp)-3'-ThymidinePhosphate
Reaction of the (Rp)-diastereoisomer of thymidine 3'-(4-nitrophenyl)phosphorothioate with styrene oxide in a medium containing water gives (Rp)-thymidine phosphate in 70percent yield with diastereoisotopomeric purity not lower than 92percent.