Novel Approach to the Synthesis of Isotopomeric MonoalkylPhosphates. The Stereospecific One-pot Conversion of (Rp)-Thymidine 3'-(Nitrophenyl)-phosphorothioate into (Rp)-3'-ThymidinePhosphate

DOI: 10.1039/c39870000594

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 594 - 595 (1987)

Update date:2022-08-16

Topics:

Authors:

Okruszek, Andrzej

Guga, Piotr

Stec, Wojciech J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39870000594

Reaction of the (R_p)-diastereoisomer of thymidine 3'-(4-nitrophenyl)phosphorothioate with styrene <(18)O>oxide in a medium containing <(17)O>water gives (R_p)-thymidine <(16)O, (17)O, (18)O>phosphate in 70percent yield with diastereoisotopomeric purity not lower than 92percent.

Full text of DOI:10.1039/c39870000594

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:[(2R,5R)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methox

Cas No:6453-60-7

R&D Labs maybe for 6453-60-7

KindChem Co.,Ltd,

Contact:+86-25-85281586

Address:13F,Bld2#,South of Longpan Road
HENAN NEW BLUE CHEMICAL CO.,LTD

website:http://www.newbluechem.com

Contact:86-371-55170693/55170694

Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China
Shandong LuZhou Amino Acid Co., Ltd

Contact:86-539-2218025

Address:yishui economic and technical development zone zhenxing south road
Xi'an Health Biochem Technology Co., Ltd.

Contact:029-62599512

Address:Li Jing Jia Yuan, Wei Qu Xi Jie, Chang'an District,Xi'an,China 710010
Shandong Xinke Petrochemical Co., Ltd.

Contact:+86-546-7277016

Address:Gudao Industrial Park, Hekou District, Dongying, Shandong Province, China

Relevant to this article

Experimental and Theoretical Study of CO₂ Insertion into Ruthenium Hydride Complexes

Doi:10.1021/acs.inorgchem.5b02556
(2016)
Two new silver(I) ammine complexes by displacement reaction between [Ag(NH₃)₂]⁺ ions and different pyridine-4,5-Imidazoledicarboxylic Acids

Doi:10.1002/zaac.201000269
(2011)
Palladium(II)- and platinum(II)-catalyzed addition of stabilized carbon nucleophiles to ethylene and propylene

Doi:10.1039/b316734h
(2004)
Doi:10.1016/0040-6031(95)02288-D
(1995)
On the mechanism of the chemiluminescent condensation of aniline with butyraldehyde catalyzed by LnCl₃ ? 6H₂O

Doi:10.1134/S0023158410040129
(2010)
Synthesis of pyrimidines and triazines in ice: Implications for the prebiotic chemistry of nucleobases

Doi:10.1002/chem.200802656
(2009)

Article Doi