2-Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as potent dissociated glucocorticoid receptor agonists
A significant improvement in agonist activity of the previously described 2-aryloctahydrophenanthrene-2,3,7-triol series of dissociated glucocorticoid receptor agonists (DAGRs) was achieved by modifying the substitution at C3 from (S)-3-hydroxy to (R)-3-h
Chantigny, Yves A.,Murray, John C.,Kleinman, Edward F.,Robinson, Ralph P.,Plotkin, Michael A.,Reese, Matthew R.,Buckbinder, Leonard,McNiff, Patricia A.,Millham, Michele L.,Schaefer, Jean F.,Abramov, Yuriy A.,Bordner, Jon
The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1-R25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment o
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(2008/06/13)
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