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64567-25-5

N-ETHYL-O-FLUOROBENZYLAMINE, also known as N-(2-Fluorobenzyl)ethanamine, is an organic compound with a molecular structure that features a fluorobenzyl group attached to an ethanamine moiety. This unique structure endows it with specific chemical properties, making it a valuable intermediate in the synthesis of various pharmaceutical compounds.
Used in Pharmaceutical Industry:
N-ETHYL-O-FLUOROBENZYLAMINE is used as a key intermediate in the synthesis of heterocycles, which are complex organic compounds with significant applications in medicinal chemistry. Specifically, it plays a crucial role in the preparation of angiotensin AT-2 receptor antagonists, a class of drugs that are instrumental in treating hypertension and heart failure by blocking the action of angiotensin II, a potent vasoconstrictor. The incorporation of N-ETHYL-O-FLUOROBENZYLAMINE in the synthesis of these heterocycles allows for the development of more effective and targeted therapies for cardiovascular diseases.

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  • 64567-25-5 Structure

  • Basic information

    1. Product Name: N-ETHYL-O-FLUOROBENZYLAMINE
    2. Synonyms: N-ETHYL-O-FLUOROBENZYLAMINE;N-(2-fluorobenzyl)ethanamine(SALTDATA: HCl);N-Ethyl-2-fluorobenzylaMine, 97%
    3. CAS NO:64567-25-5
    4. Molecular Formula: C9H12FN
    5. Molecular Weight: 153.2
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 64567-25-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 193.2°C at 760 mmHg
    3. Flash Point: 70.6°C
    4. Appearance: /
    5. Density: 1.009g/cm3
    6. Vapor Pressure: 0.471mmHg at 25°C
    7. Refractive Index: 1.491
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: N-ETHYL-O-FLUOROBENZYLAMINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: N-ETHYL-O-FLUOROBENZYLAMINE(64567-25-5)
    12. EPA Substance Registry System: N-ETHYL-O-FLUOROBENZYLAMINE(64567-25-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 64567-25-5(Hazardous Substances Data)

64567-25-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 64567-25-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,5,6 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 64567-25:
(7*6)+(6*4)+(5*5)+(4*6)+(3*7)+(2*2)+(1*5)=145
145 % 10 = 5
So 64567-25-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H12FN/c1-2-11-7-8-5-3-4-6-9(8)10/h3-6,11H,2,7H2,1H3

64567-25-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl-(2-fluoro-benzyl)-amine

1.2 Other means of identification

Product number -
Other names N-(2-FLUOROBENZYL)ETHANAMINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:64567-25-5 SDS

64567-25-5Relevant articles and documents

Pyrano-[2,3b]-pyridines as potassium channel antagonists

Finlay, Heather J.,Lloyd, John,Nyman, Michael,Conder, Mary Lee,West, Tonya,Levesque, Paul,Atwal, Karnail

, p. 2714 - 2718 (2008/12/21)

The design and synthesis of a series of highly functionalized pyrano-[2,3b]-pyridines is described. These compounds were assayed for their ability to block the IKur channel encoded by the gene hKV1.5 in patch-clamped L-929 cells. Six of the compounds in this series showed sub-micromolar activity, the most potent being 4-(4-ethyl-benzenesulfonylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3b]-pyridine-6-carboxylic acid ethyl-phenyl-amide with an IC50 of 378 nM.

Central cholinergic agents. I. Potent acetylcholinesterase inhibitors, 2-[ω-[N-alkyl-N-(ω-phenylalkyl)amino]alkyl]-1H-isoindole-1,3(2H)-dion es, based on a new hypothesis of the enzyme's active site

Ishihara,Kato,Goto

, p. 3225 - 3235 (2007/10/02)

It has been suggested that the active site of acetylcholinesterase contains a hydrophobic binding site (HBS-1), which is closely adjacent to both the anionic and the esteratic sites. In this paper, we assumed that there exists another hydrophobic binding site (HBS-2), some distance removed from the anionic site. On this assumption, a new working hypothesis was proposed for the design of acetylcholinesterase inhibitors. A series of 2-[ω-[N-alkyl-N-(ω-phenylalkyl)amino]alkyl]-1H-isoindole-1,3(2H)-dion es was designed based on this hypothesis and tested for its inhibitory activities on acetylcholinesterase. Some in this series were revealed to be more potent than physostigmine. Optimum activity was found to be associated with a five carbon chain length separating the benzylamino group from the 1H-isoindole-1,3(2H)-dione (phthalimide) moiety. Quantitative study of substitution effect on the phthalimide moiety revealed that hydrophilic and electron-withdrawing groups enhance the activity.

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