646522-92-1

Basic information

• Product Name: Ethanone, 2-cyclopropyl-1-(2-methoxyphenyl)- (9CI)
• Synonyms: Ethanone, 2-cyclopropyl-1-(2-methoxyphenyl)- (9CI)
• CAS NO: 646522-92-1
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.23836
• Product Categories: METHOXY
• Mol File: 646522-92-1.mol

Chemical Properties

• Boiling Point: 294.7±13.0 °C(Predicted)
• Appearance: /
• Density: 1.091±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Ethanone, 2-cyclopropyl-1-(2-methoxyphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-cyclopropyl-1-(2-methoxyphenyl)- (9CI)(646522-92-1)
• EPA Substance Registry System: Ethanone, 2-cyclopropyl-1-(2-methoxyphenyl)- (9CI)(646522-92-1)

Safety Data

• Hazardous Substances Data: 646522-92-1(Hazardous Substances Data)

Upstream product

• 5239-82-7 cyclopropylacetic acid 

Downstream Products

• 646522-76-1 trifluoromethanesulfonic acid 2-(2-cyclopropylacetyl)phenyl ester 
• 646522-95-4 2-cyclopropyl-1-(2-hydroxy-phenyl)-ethanone 

Relevant articles and documents

Unexpected Migration and Oxidative Cyclization of Substituted 2-Acetophenone Triflates under Basic Conditions: Synthetic and Mechanistic Insights

Oxidative ring closure of alkyl-substituted 2-hydroxyacetophenone trifluoromethanesulfonate esters (triflates) occurs upon exposure to base in anaerobic DMF at 20-90 °C. Alkyl substitution is required for ring closure. A migrated enol triflate product forms at lower temperature in high yield via migration of the trifluoromethanesulfonate in the unsubstituted and monoalkyl-substituted cases. The alkyl-substituted enol triflates also enter into the benzofuran-3-one ring-forming process under thermal cyclization conditions. Potential mechanistic pathways are evaluated.