5239-82-7Relevant articles and documents
Rhodes,Vargas
, p. 4077,4078 (1973)
Oxidation of Alkynyl Boronates to Carboxylic Acids, Esters, and Amides
Li, Chenchen,Li, Ruoling,Zhang, Bing,Zhao, Pei,Zhao, Wanxiang
supporting information, p. 10913 - 10917 (2020/05/25)
A general efficient protocol was developed for the synthesis of carboxylic acids, esters, and amides through oxidation of alkynyl boronates, generated directly from terminal alkynes. This protocol represents the first example of C(sp)?B bond oxidation. This approach displays a broad substrate scope, including aryl and alkyl alkynes, and exhibits excellent functional group tolerance. Water, primary and secondary alcohols, and amines are suitable nucleophiles for this transformation. Notably, amino acids and peptides can be used as nucleophiles, providing an efficient method for the synthesis and modification of peptides. The practicability of this methodology was further highlighted by the preparation of pharmaceutical molecules.
Cyclopropylacetic acid production method
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Paragraph 0019; 0022, (2019/10/01)
The invention relates to a novel synthesis route of cyclopropylacetic acid. Diethyl malonate is used as a raw material, and through three steps of reactions of a substitution reaction, a hydrolysis reaction and a decarboxylic reaction, the cyclopropylacetic acid is synthesized with a high yield. The provided cyclopropylacetic acid production method is a production method which is high in yield, low in cost, easy to operate and suitable for industrialization.