Metal-free18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation
A metal-free and selective method to form [18F]aryl-CF2H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C-H activation of benzylic C-H bonds has been developed. The method is operationally simple and tolerates a variety of electron-neutral/deficient arenes and heteroarenes.
Yuan, Gengyang,Wang, Feng,Stephenson, Nickeisha A.,Wang, Lu,Rotstein, Benjamin H.,Vasdev, Neil,Tang, Pingping,Liang, Steven H.
supporting information
p. 126 - 129
(2016/12/27)
Transition-metal-free C-H oxidative activation: Persulfate-promoted selective benzylic mono- and difluorination
An operationally simple and selective method for the direct conversion of benzylic C-H to C-F to obtain mono- and difluoromethylated arenes using Selectfluor as a fluorine source is developed. Persulfate can be used to selectively activate benzylic hydrogen atoms toward C-F bond formation without the aid of transition metal catalysts.
Ma, Jing-Jing,Yi, Wen-Bin,Lu, Guo-Ping,Cai, Chun
supporting information
p. 2890 - 2894
(2015/04/27)
Silver-catalyzed oxidative activation of benzylic C-H bonds for the synthesis of difluoromethylated arenes
A mild and catalytic method to form difluoromethylated arenes through the activation of benzylic C-H bonds has been developed. Utilizing AgNO3 as the catalyst, various arenes with diverse functional groups undergo activation/fluorination of ben
Xu, Peng,Guo, Shuo,Wang, Liyan,Tang, Pingping
supporting information
p. 5955 - 5958
(2014/06/10)
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