- Bromoderivatives of gramines. Preparation and pharmacological properties
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Bromination of gramine (I), 1-methylgramine (IX), 2-methylgramine (IV) and 1,2-dimethylgramine (XV) with different mole ratios of bromine to substrate was investigated; it was seen that the 5- and 6-position are the normal sites of bromination and 1-methylgramines (IX) and (XV) give better yields of bromoderivatives.Among the compounds submitted the pharmacological screening, 2,6-dibromo-1-methylgramine hydrobromide (Xa) and especially 6-bromo-2-methylgramine (V) showed a clear antiserotoninic antiinflammatory and analgesic activity.Furthermore gramine (V) showed a good anti prostaglandin synthetase activity in vitro.Key-words: Bromogramines. - Antiserotonic activity. - Antiinflammatory activity.
- Franzone, Jose Sebastian,Cirillo, Rocco,Cravanzola, Carlo
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p. 261 - 268
(2007/10/02)
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- GRAMINE-DERIVED BROMO-ALKALOIDS FROM THE MARINE BRYOZOAN ZOOBOTRYON VERTICILLATUM
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Two new natural products, 2,5,6-tribromo-N-methylgramine (1) and its corresponding sidechain N-oxide, 2, have been isolated from the subtropical marine bryozoan Zoobotryon verticillatum.The structures of these compounds were illustrated by spectral analyses and by chemical synthesis.
- Sato, Aiya,Fenical, William
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p. 481 - 484
(2007/10/02)
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