64945-29-5

Upstream product

• 52972-61-9 3-(N,N-dimethylaminomethyl)-1-methylindole 
• 87401-29-4 1-methylgramine hydrochloride 
• 85908-65-2 C₁₂H₁₃Br₃N₂O 
• 87401-27-2 2,6-dibromo-1-methylgramine hydrobromide 
• 87-52-5 3-(Dimethylaminomethyl)indole 

Relevant academic research and scientific papers

GRAMINE-DERIVED BROMO-ALKALOIDS FROM THE MARINE BRYOZOAN ZOOBOTRYON VERTICILLATUM

Two new natural products, 2,5,6-tribromo-N-methylgramine (1) and its corresponding sidechain N-oxide, 2, have been isolated from the subtropical marine bryozoan Zoobotryon verticillatum.The structures of these compounds were illustrated by spectral analyses and by chemical synthesis.

Bromoderivatives of gramines. Preparation and pharmacological properties

Bromination of gramine (I), 1-methylgramine (IX), 2-methylgramine (IV) and 1,2-dimethylgramine (XV) with different mole ratios of bromine to substrate was investigated; it was seen that the 5- and 6-position are the normal sites of bromination and 1-methylgramines (IX) and (XV) give better yields of bromoderivatives.Among the compounds submitted the pharmacological screening, 2,6-dibromo-1-methylgramine hydrobromide (Xa) and especially 6-bromo-2-methylgramine (V) showed a clear antiserotoninic antiinflammatory and analgesic activity.Furthermore gramine (V) showed a good anti prostaglandin synthetase activity in vitro.Key-words: Bromogramines. - Antiserotonic activity. - Antiinflammatory activity.