64945-29-5

Upstream product

• 52972-61-9 3-(N,N-dimethylaminomethyl)-1-methylindole 
• 87401-29-4 1-methylgramine hydrochloride 
• 87-52-5 3-(Dimethylaminomethyl)indole 
• 87401-27-2 2,6-dibromo-1-methylgramine hydrobromide 
• 85908-65-2 C₁₂H₁₃Br₃N₂O 

Relevant academic research and scientific papers

Bromoderivatives of gramines. Preparation and pharmacological properties

Bromination of gramine (I), 1-methylgramine (IX), 2-methylgramine (IV) and 1,2-dimethylgramine (XV) with different mole ratios of bromine to substrate was investigated; it was seen that the 5- and 6-position are the normal sites of bromination and 1-methylgramines (IX) and (XV) give better yields of bromoderivatives.Among the compounds submitted the pharmacological screening, 2,6-dibromo-1-methylgramine hydrobromide (Xa) and especially 6-bromo-2-methylgramine (V) showed a clear antiserotoninic antiinflammatory and analgesic activity.Furthermore gramine (V) showed a good anti prostaglandin synthetase activity in vitro.Key-words: Bromogramines. - Antiserotonic activity. - Antiinflammatory activity.

GRAMINE-DERIVED BROMO-ALKALOIDS FROM THE MARINE BRYOZOAN ZOOBOTRYON VERTICILLATUM

Two new natural products, 2,5,6-tribromo-N-methylgramine (1) and its corresponding sidechain N-oxide, 2, have been isolated from the subtropical marine bryozoan Zoobotryon verticillatum.The structures of these compounds were illustrated by spectral analyses and by chemical synthesis.