A novel C-C bond formation reaction with 1-methoxymethylindolylborate
The reaction of 1-methoxymethylindolylborates 2 with electrophiles in the presence of benzaldehyde enabled the novel construction of tri-substituted indoles in a 'one-pot' procedure.
Ishikura, Minoru,Kato, Hiromi,Ohnuki, Nobuyuki
p. 220 - 221
(2007/10/03)
Palladium-catalyzed carbonylative cross-coupling reaction with triethyl(1-methylindol-2-yl)borate: A simple route to 1-methylindol-2-yl ketones
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Ishikura,Terashima
p. 2634 - 2637
(2007/10/02)
VINYLOXYBORANE PROMOTED 1,4-ADDITION OF TRIETHYL(1-METHYLINDOL-2-YL)BORATE TO 2-CYCLOALKENONES
The conjugate addition reaction of triethyl(1-methylindol-2-yl)borate to 2-cycloalkenone could be effected with a catalytic amount of vinyloxyborane.
Ishikura, Minoru,Terashima, Masanao
p. 2091 - 2094
(2007/10/02)
Functionalization of the Methyl Group of 2-Methylindole by Direct Generation of a C,N-Dianion
The first method for directly generating C,N-dianion from an alkyl-substituted ?-excessive N-heterocyclic compound (2-methylindole) has been developed.It involves treatment with 3 equiv. of BuLi and 2 equiv. of ButOK in a particular sequence and results in the functionalization of the 2-methyl group of the indole in a regiospecific manner.
Novel Aspects on the Reaction of Trialkyl-(1-methylindol-2-yl)borates
A new use of trialkyl-(1-methylindol-2-yl)borates for the synthesis of 2-substituted indoles involving the palladium catalysed cross-coupling with vinylic and aromatic halides, or a facile alkyl migration from boron to carbon without an additional electrophile is described.
Ishikura, Minoru,Terashima, Masanao
p. 135 - 136
(2007/10/02)
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