Parallel Synthesis of New β2-Amino Esters via Conjugate Nucleophilic Additions
The Michael addition of secondary cyclic aromatic and nonaromatic amines to methyl 2-{[(tert-butoxycarbonyl)amino]methyl}acrylate afforded substituted β2-amino esters in good to excellent yields.
Huck, Jacques,Duru, Christiane,Roumestant, Marie Louise,Martinez, Jean
Synthesis of enantiopure β2-homoalanine derivatives via rhodium catalyzed asymmetric hydrogenation
The stereoselective synthesis of chiral β2-homoalanine derivatives with 99% ee by the Rh-catalyzed enantioselective hydrogenation of prochiral 2-aminomethyl acrylates is described. The subsequent transformation to chiral 3-amino-2-methylpropanols is also demonstrated.