651724-25-3

Basic information

• Product Name: 2-Propenoicacid,2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-,methyl
• Synonyms: 2-Propenoicacid,2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-,methyl
• CAS NO: 651724-25-3
• Molecular Formula: C₁₀H₁₇NO₄
• Molecular Weight: 0
• Product Categories: N-BOC
• Mol File: 651724-25-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenoicacid,2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-,methyl(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoicacid,2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-,methyl(651724-25-3)
• EPA Substance Registry System: 2-Propenoicacid,2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-,methyl(651724-25-3)

Safety Data

• Hazardous Substances Data: 651724-25-3(Hazardous Substances Data)

Upstream product

• 51779-32-9 iminodicarboxylic acid di-tert-butyl ester 
• 15484-46-5 methyl 2-hydroxymethylacrylate 
• 4224-69-5 methyl 2-(bromomethyl)propenoate 
• 374905-29-0 methyl 2-{[bis(tert-butoxycarbonyl)amino]methyl}acrylate 

Downstream Products

• 168828-18-0 methyl (S)-3-(tert-butoxycarbonylamino)-2-methylpropanoate 
• 182486-32-4 (R)-methyl 3-{[(tert-butoxy)carbonyl]amino}-2-methylpropionate 
• 1429320-37-5 (E)-methyl 3-(tert-butoxycarbonylamino)-2-methylacrylate 
• 1429320-36-4 (Z)-methyl 3-(tert-butoxycarbonylamino)-2-methylacrylate 

Relevant articles and documents

Parallel Synthesis of New β2-Amino Esters via Conjugate Nucleophilic Additions

The Michael addition of secondary cyclic aromatic and nonaromatic amines to methyl 2-{[(tert-butoxycarbonyl)amino]methyl}acrylate afforded substituted β2-amino esters in good to excellent yields.

Synthesis of enantiopure β2-homoalanine derivatives via rhodium catalyzed asymmetric hydrogenation

The stereoselective synthesis of chiral β2-homoalanine derivatives with 99% ee by the Rh-catalyzed enantioselective hydrogenation of prochiral 2-aminomethyl acrylates is described. The subsequent transformation to chiral 3-amino-2-methylpropanols is also demonstrated.