182486-32-4

Basic information

• Product Name: Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, methyl
• Synonyms: Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, methyl
• CAS NO: 182486-32-4
• Molecular Formula: C₁₀H₁₉NO₄
• Molecular Weight: 217.26216
• Product Categories: N-BOC
• Mol File: 182486-32-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, methyl(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, methyl(182486-32-4)
• EPA Substance Registry System: Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, methyl(182486-32-4)

Safety Data

• Hazardous Substances Data: 182486-32-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 92535-26-7 methyl 3-amino-(2R)-2-methylpropanoate 
• 84506-41-2 methyl (2R)-3-azido-2-methylpropanoate 
• 4224-69-5 methyl 2-(bromomethyl)propenoate 
• 374905-29-0 methyl 2-{[bis(tert-butoxycarbonyl)amino]methyl}acrylate 
• 651724-25-3 methyl 2-{[(tert-butoxycarbonyl)amino]methyl}acrylate 
• 15484-46-5 methyl 2-hydroxymethylacrylate 
• 80-62-6 methacrylic acid methyl ester 
• 176257-79-7 (αS,2R)-methyl N-α-methylbenzyl-3-amino-2-methylpropanoate 
• 220116-91-6 (2S,5R)-2-tert-Butyl-4-methoxy-5-methyl-5,6-dihydro-2H-pyrimidine-1-carboxylic acid tert-butyl ester 
• 72657-23-9 methyl (R)-3-hydroxy-2-methylpropionate 
• 84341-94-6 methyl (R)-2-methyl-3-[(4'-toluenesulfonyl)oxy]propionate 
• 935748-99-5 (-)-(R)-3-((tert-butoxycarbonyl)(p-toluenesulfonyl)amino)-2-methylpropionic acid 

Downstream Products

• 162465-50-1 (R)-3-<(tert-butoxycarbonyl)amino>-2-methylpropan-1-ol 
• 281191-03-5 (2S,2'R,1''S,2''R,1''''R)1''-(3'''-{1''''-[(tert-butoxy)carbonyl]-2''''-p-methoxyphenylethylcarbamoyl}allyl)-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}-2'-methylpropionyl)oxy]-4-methylpentanoate 
• 245125-88-6 (2S,2'R)-benzyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}-2'-methylpropinoyl)oxy]-4-methylpentanoate 
• 132696-45-8 (R)-2-{[(tert-butoxycarbonyl)amino]methyl}propionic acid 

Relevant articles and documents

TRIAZACYCLODODECANSULFONAMIDE ("TCD")-BASED PROTEIN SECRETION INHIBITORS

Provided herein are triazacyclododecansulfonamide ("TCD")-based protein secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I) and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.

Synthesis of optically active bifunctional building blocks through enantioselective copper-catalyzed allylic alkylation using Grignard reagents

Enantioselective copper-catalyzed allylic alkylations were performed on allylic bromides with a protected hydroxyl or amine functional group using several Grignard reagents and Taniaphos L1 as a ligand. The terminal olefin moiety in the products was transformed into various functional groups without racemization, providing facile access to a variety of versatile bifunctional chiral building blocks.

Asymmetric syntheses of potent antitumor macrolides cryptophycin B and arenastatin A

Efficient and highly stereoselective syntheses of cryptophycin B and arenastatin A, potent cytotoxic agents, are described. An ester-derived titanium enolate mediated syn-aldol reaction was employed to generate the stereocenters C-5 and C-6. The route is convergent and provides a convenient access to the synthesis of structural variants of cryptophycins as well as members of its family. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).