651744-22-8

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridin-5-ol, 4-fluoro-1-[tris(1-methylethyl)silyl]-
• Synonyms: 4-Fluoro-5-hydroxy-1-triisopropylsilyl-7-azaindole;1H-Pyrrolo[2,3-b]pyridin-5-ol, 4-fluoro-1-[tris(1-methylethyl)silyl]-;4-fluoro-1-tri(propan-2-yl)silylpyrrolo[2,3-b]pyridin-5-ol
• CAS NO: 651744-22-8
• Molecular Formula: C16H25FN2OSi
• Molecular Weight: 308.47
• Mol File: 651744-22-8.mol

Chemical Properties

• Boiling Point: 335.819°C at 760 mmHg
• Flash Point: 156.898°C
• Appearance: /
• Density: 1.091g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridin-5-ol, 4-fluoro-1-[tris(1-methylethyl)silyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridin-5-ol, 4-fluoro-1-[tris(1-methylethyl)silyl]-(651744-22-8)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridin-5-ol, 4-fluoro-1-[tris(1-methylethyl)silyl]-(651744-22-8)

Safety Data

• Hazardous Substances Data: 651744-22-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H25FN2OSi/c1-10(2)21(11(3)4,12(5)6)19-8-7-13-15(17)14(20)9-18-16(13)19/h7-12,20H,1-6H3

Upstream product

• 640735-25-7 4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

PYRROLOPYRIDINES AS KINASE INHIBITORS

Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.Formula, (I).

Synthesis of functionalized 7-azaindoles via directed ortho-metalations

Functionalization at C-5 of 4-fluoro- and 4-chloro-1-triisopropylsilyl-7- azaindole, 1 and 2, respectively, leads to a variety of new substituted 7-azaindole derivatives. We also describe two approaches to introduce functionality at C-6.