655256-68-1

Basic information

• Product Name: 1-[2-(4-Methylpiperazin-1-yl)phenyl]methanamine
• Synonyms: 2-(4-Methylpiperazin-1-yl)benzylamine 97%;[2-(4-Methylpiperazin-1-yl)phenyl]methylamine 97%;2-(4-Methylpiperazin-1-yl)benzylamine, 1-[2-(Aminomethyl)]phenyl]-4-methylpiperazine;[2-(4-Methylpiperazin-1-yl)phenyl]methylamine;1-[2-(4-Methylpiperazin-1-yl)phenyl]methamine;ART-CHEM-BB B021975;AKOS B021975;2-(4-METHYLPIPERAZINO)BENZYLAMINE
• CAS NO: 655256-68-1
• Molecular Formula: C₁₂H₁₉N₃
• Molecular Weight: 205.3
• EINECS: 1312995-182-4
• Product Categories: Amines and Anilines;Heterocycles;Piperaizine;Piperazidine intermediates;Piperazines
• Mol File: 655256-68-1.mol

Chemical Properties

• Boiling Point: 337.6 °C at 760 mmHg
• Flash Point: 155.7 °C
• Appearance: /
• Density: 1.065 g/cm³
• Vapor Pressure: 0.000104mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 1-[2-(4-Methylpiperazin-1-yl)phenyl]methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(4-Methylpiperazin-1-yl)phenyl]methanamine(655256-68-1)
• EPA Substance Registry System: 1-[2-(4-Methylpiperazin-1-yl)phenyl]methanamine(655256-68-1)

Safety Data

• Hazard Codes: C
• Statements: 21/22-34
• Safety Statements: 23-26-36/37/39-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 655256-68-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-[2-(4-Methylpiperazin-1-yl)phenyl]methanamine is used as a reagent in organic synthesis for its ability to participate in various chemical reactions, facilitating the creation of new compounds and contributing to the advancement of chemical research.
Used in Pharmaceutical Research and Development:
Due to its structural similarity to other biologically active compounds, 1-[2-(4-Methylpiperazin-1-yl)phenyl]methanamine is used as a potential candidate in pharmaceutical research and development. Its unique structural features make it a valuable asset for exploring new therapeutic agents and drug discovery.
Used in Medicinal Chemistry:
1-[2-(4-Methylpiperazin-1-yl)phenyl]methanamine is utilized in medicinal chemistry for its potential to contribute to the design and synthesis of new drugs. Its unique structural elements offer opportunities for the development of novel therapeutic agents with improved efficacy and selectivity.

InChI:InChI=1/C12H19N3/c1-14-6-8-15(9-7-14)12-5-3-2-4-11(12)10-13/h2-5H,6-10,13H2,1H3

Upstream product

• 85803-63-0 2-(4-methylpiperazin-1-yl)benzonitrile 
• 85803-62-9 2-(4-methylpiperazin-1-yl)benzaldehyde 

Downstream Products

• 1028336-89-1 4-chloro-6-[2-(4-methyl-piperazin-1-yl)-benzylamino]-2H-phthalazin-1-one 
• 1426531-12-5 6-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide 
• 1426530-96-2 6-(1-methyl-1H-pyrazol-5-yl)-N-(2-methyl-5-((2-(4-methylpiperazin-1-yl)benzyl)carbamoyl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide 
• 1426531-14-7 N-(2-bromo-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426531-15-8 3-amino-4-bromo-N-(2-(4-methylpiperazin-1-yl)benzyl)benzamide 
• 1426530-69-9 7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426531-72-7 5-amino-2-fluoro-4-methyl-N-(2-(4-methylpiperazin-1-yl )benzyl)benzamide 
• 1426531-74-9 3-amino-4-methyl-N-(2-(4-methylpiperazin-1-yl)benzyl)benzamide 
• 1426530-72-4 7-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide 

Relevant articles and documents

PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY

The invention relates to a compound of the Formula (I) or salt thereof wherein Rx, Ry, Rz, R5, R6, A, B, L, n and m are as defined in the description. The invention also relates to pharmaceutical compositions of said compounds, the use of said compounds as medicaments and in the production of an anti-angiogenic effect in a warm blooded animal. The invention also relates to processes for the preparation of said compounds.

PIPERAZINYLPHENALKYL LACTAM/AMINE LIGANDS FOR THE 5HT1B RECEPTOR

The present invention relates to novel derivatives, that are compounds of Formula (I), wherein R1, R2, R3, R14, X, Y, n and m are defined herein, their pharmaceutically acceptable salts, pharmaceutical compositions and methods using said compounds in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors, specifically, antagonists of 5-HT1B are useful.