- Method for preparing organophosphate compound from P(O)-OH-containing compound and alcohol through efficient esterification
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The invention provides a method for efficiently and highly selectively synthesizing an organophosphate derivative containing different substitute functional groups. The method is characterized by adopting a polypeptide catalyst as a condensation reagent, taking a P(O)-OH-containing compound and alcohol as reaction substrates, and adding an organic solvent in a reaction system. The method disclosed by the invention has the advantages that the catalyst is cheap in cost and easy to obtain; the substrate applicability is high; reaction conditions are mild, safe and reliable; the selectivity of an obtained target product is close to 100 percent, and the yield is up to 90 percent or more. According to the method provided by the invention, the defects of a traditional method for synthesizing an organophosphate compound that the reaction selectivity is poor, the reaction steps are tedious, the yield is low, reagents which are harmful to the environment are required to be used, and the like are solved, and a good industrial application prospect is obtained. Meanwhile, the invention also provides the corresponding organophosphate derivative containing different substitute functional groups.
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Paragraph 0042
(2017/07/21)
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- THE EFFECT OF ADDED LITHIUM CATIONS ON THE STEREOCHEMISTRY OF NUCLEOPHILIC DISPLACEMENT REACTIONS AT PHOSPHORUS
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Added lithium cation has no effect on the stereochemical outcome of the displacement of chloride or p-nitrophenoxide from phosphorus in acyclic and some cyclic molecules.In other cyclic systems the preponderant stereochemistry can be biased from inversion to retention of configuration.
- Hall, C. Richard,Inch, Thomas D.,Pottage, Colin
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p. 229 - 232
(2007/10/02)
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- Selective phosphorylation process
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A one step process for the preparation of phosphate esters of phenol comprising reacting phenol with a dimethyl disulfide and a trialkyl phosphite.
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