3-AMINO-2-HRYDROXYALKANOIC ACIDS AND THEIR PRODRUGS
Compounds having the formula are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting a
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Page 16
(2010/02/06)
3-Amino-2-hydroxyalkanoic acids and their prodrugs
Compounds having the formula are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting a
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Page/Page column 8
(2010/02/07)
3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2
Substituted 3-amino-2-hydroxyamides and related hydroxyamides and acylhydrazines were identified as inhibitors of human methionine aminopeptidase-2 (MetAP2). Examination of substituents through parallel synthesis and iterative structure-based design allow
Sheppard, George S.,Wang, Jieyi,Kawai, Megumi,BaMaung, Nwe Y.,Craig, Richard A.,Erickson, Scott A.,Lynch, Linda,Patel, Jyoti,Yang, Fan,Searle, Xenia B.,Lou, Pingping,Park, Chang,Kim, Ki H.,Henkin, Jack,Lesniewski, Richard
p. 865 - 868
(2007/10/03)
Hydrazide and alkoxyamide angiogenesis inhibitors
Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.
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(2008/06/13)
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