65964-64-9

Basic information

• Product Name: Imidazo[1,2-a]pyridine, 2-[1,1'-biphenyl]-4-yl-7-methyl-
• CAS NO: 65964-64-9
• Molecular Formula: C20H16N2
• Molecular Weight: 284.36
• Mol File: 65964-64-9.mol

Chemical Properties

• CAS DataBase Reference: Imidazo[1,2-a]pyridine, 2-[1,1'-biphenyl]-4-yl-7-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyridine, 2-[1,1'-biphenyl]-4-yl-7-methyl-(65964-64-9)
• EPA Substance Registry System: Imidazo[1,2-a]pyridine, 2-[1,1'-biphenyl]-4-yl-7-methyl-(65964-64-9)

Safety Data

• Hazardous Substances Data: 65964-64-9(Hazardous Substances Data)

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 135-73-9 2-Bromo-4'-phenylacetophenone 
• 92-91-1 biphenyl-4-acetaldehyde 

Downstream Products

• 65964-52-5 2-biphenyl-4-yl-7-(trans-2-thiophen-2-yl-vinyl)-imidazo[1,2-a]pyridine 
• 65964-24-1 7-(trans-2-benzo[1,3]dioxol-5-yl-vinyl)-2-biphenyl-4-yl-imidazo[1,2-a]pyridine 
• 65964-43-4 2-biphenyl-4-yl-7-(trans-2-dibenzofuran-3-yl-vinyl)-imidazo[1,2-a]pyridine 
• 440345-77-7 (2-biphenyl-4-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-methanol 

Relevant articles and documents

Solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines by grindstone chemistry

The present work describes the solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines in excellent to nearly quantitative yields from 2-aminopyridines and a wide variety of ω-bromomethylketones using a grindstone procedure at 25°C to 30°C for 3 to

One-Pot Sequential Bromination and Fluorination to Access 3-Fluoroimidazo[1,2-a]pyridines from Arylketones

3-Fluoro-2-arylimidazo[1,2-a]pyridines were selectively synthesised in one-pot from acetophenones and 2-aminopyridines under mild conditions. The sequence of reactions involved bromination, condensation, and late-stage fluorination. Two halogenating reagents play key roles in the process. We found that tetrabutylammonium tribromide and SelectfluorTM gave excellent yields of the desired products in the one-pot sequential reaction.

Influence of 2-substituent on the activity of imidazo[1,2-a] pyridine derivatives against human cytomegalovirus

The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by 1H and 13C NMR spectra. A conformational study was obtained by X-ray crystallographic analysis for 2-biphen-4-ylimidazopyridine 7. The antiviral activity against human cytomegalovirus (HCMV) was investigated. It was strongly influenced by the nature of C-2 substituent. Copyright