65996-11-4

Basic information

• Product Name: 2,4-Pentadienoic acid, 2-cyano-5-(dimethylamino)-3-methyl-, ethyl ester
• CAS NO: 65996-11-4
• Molecular Formula: C11H16N2O2
• Molecular Weight: 208.26
• Mol File: 65996-11-4.mol

Chemical Properties

• CAS DataBase Reference: 2,4-Pentadienoic acid, 2-cyano-5-(dimethylamino)-3-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pentadienoic acid, 2-cyano-5-(dimethylamino)-3-methyl-, ethyl ester(65996-11-4)
• EPA Substance Registry System: 2,4-Pentadienoic acid, 2-cyano-5-(dimethylamino)-3-methyl-, ethyl ester(65996-11-4)

Safety Data

• Hazardous Substances Data: 65996-11-4(Hazardous Substances Data)

Usage

Pentadienoic acid group

A group consisting of two carbon-carbon double bonds separated by a single bond in a five-carbon chain, contributing to the compound's reactivity and potential applications in organic synthesis.

Cyano group

A cyanide group (CN) bonded to a carbon atom, providing the compound with a strong electron-withdrawing effect and contributing to its potential use as a photoinitiator.

Dimethylamino group

A nitrogen atom bonded to two methyl groups (CH3), providing the compound with basicity and potential for hydrogen bonding, which can affect its solubility and reactivity.

Ethyl ester functional group

An ester group (C=O) bonded to an ethyl group (CH2CH3), providing the compound with potential for hydrolysis and reactivity in organic synthesis.

Reagent in organic synthesis

The compound's reactive functional groups make it a useful reagent in organic synthesis, allowing for the formation of a variety of new compounds through chemical reactions.

Building block in pharmaceuticals and agrochemicals

The compound's unique structure and reactivity make it a valuable building block in the production of various pharmaceuticals and agrochemicals, with potential for the development of new drugs and pesticides.

Potential as a photoinitiator

The presence of the cyano group gives the compound potential as a photoinitiator for polymerization reactions, allowing for the formation of polymers with specific properties.

Precursor for bioactive molecules

The compound's unique structure and functional groups make it a potential precursor for the synthesis of bioactive molecules, which could have applications in medicine or agriculture.

Toxic if ingested or inhaled

The compound can be toxic if ingested or inhaled, and should be handled with caution to avoid exposure.

Skin and eye irritation

The compound may cause skin and eye irritation upon contact, and appropriate personal protective equipment should be worn when handling it.

Flammable

The compound has the potential to be flammable, and should be stored and handled in accordance with proper safety protocols to avoid fire or explosion hazards.

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 759-58-0 ethyl isopropylidenecyanoacetate 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 93271-59-1 1,2-dihydro-2-oxo-4-methylpyridine-3-carbonitrile 
• 50840-02-3 ethyl 2-chloro-4-methyl-3-pyridinecarboxylate 
• 1420830-43-8 C₁₇H₁₅N₅O 
• 1420830-42-7 C₁₇H₁₆N₂O₂ 
• 1420830-41-6 C₁₆H₁₂N₂O₂ 
• 1420830-40-5 C₁₆H₁₄N₂O₂ 
• 1420830-39-2 C₁₈H₁₆N₂O₃ 
• 1420830-37-0 C₁₉H₂₀N₂O₃ 
• 1420830-36-9 C₁₅H₁₄N₂O 
• 1420830-35-8 C₁₃H₁₁BrN₂O 
• 65996-07-8 2-bromo-4-methyl-3-pyridinecarboxylic acid 
• 65996-17-0 ethyl 2-bromo-4-methylnicotinic acid 
• 1420830-38-1 C₁₈H₁₈N₂O₄ 
• 1420626-92-1 C₁₇H₁₇N₃O 

Relevant articles and documents

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One aspect of the invention relates to a series of new PCSK9 inhibitor compounds comprising piperidine ring structures, including compounds of formula (I) and/or pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating PCSK9 receptor related diseases comprising administration of one or more compounds of formula (I) or a pharmaceutically acceptable salt thereof.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

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HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

2-PHENYLNICOTINIC ACID DERIVATIVE

The present invention is to provide the compounds useful as a treating or preventing agent for gout and hyperuricemia which are 2-phenylnicotinic acid derivatives having a uric acid lowering action due to an excellent xanthine oxidase inhibitory action. Since the 2-phenylnicotinic acid derivatives of the present invention exhibit a uric acid lowering action due to an excellent xanthine oxidase inhibitory action and also hypolipemic action, their utility is very high as a treating or preventive agent for gout and hyperuricemia which are often accompanied by hyperlipemia as a complication.

SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM ACETONE AND ETHYL CYANOACETATE

A method for making 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate, as depicted in the following reaction scheme.

ACETALS OF LACTAMS AND ACID AMIDES: 42.* CYCLIZATION OF DIENAMINO ESTERS; DIENOAMINE NITRILES; AND ACYLAMIDINES TO PYRIDINE DERIVATIVES

The reaction of derivatives of alkylidene(cycloalkylidene)cyanoacetic ester, -malonodinitrile , and -cyanoacetamide with dimethylformamide diethylacetal with subsequent cyclization of the resulting enamine systems gives derivatives of pyridine, 2-pyridine, and isoquinoline. 2-Amino-3-cyano-4-methylpyridine, which was synthesized by this method, was converted to a pyridopyrimidine derivative.