50840-02-3

Basic information

• Product Name: 2-CHLORO-4-METHYL-NICOTINIC ACID ETHYL ESTER
• Synonyms: 2-CHLORO-4-METHYL-NICOTINIC ACID ETHYL ESTER;Ethyl 2-chloro-4-methylnicotinate
• CAS NO: 50840-02-3
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.64
• Mol File: 50840-02-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 274.725°C at 760 mmHg
• Flash Point: 119.95°C
• Appearance: /
• Density: 1.208g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• PKA: -0.52±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-METHYL-NICOTINIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-METHYL-NICOTINIC ACID ETHYL ESTER(50840-02-3)
• EPA Substance Registry System: 2-CHLORO-4-METHYL-NICOTINIC ACID ETHYL ESTER(50840-02-3)

Safety Data

• Hazardous Substances Data: 50840-02-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H10ClNO2/c1-3-13-9(12)7-6(2)4-5-11-8(7)10/h4-5H,3H2,1-2H3

Upstream product

• 124571-74-0 1-Carbethoxy-1-cyan-4-dimethylamino-2-methylbuta-1,3-dien 
• 759-58-0 ethyl isopropylidenecyanoacetate 
• 105-56-6 ethyl 2-cyanoacetate 
• 152362-00-0 ethyl 2-chloro-2-cyano-3-methyl-5-oxopentanoate 
• 65996-11-4 1-carbethoxy-1-cyano-2-methyl-4-dimethylamino-1,4-butadiene 

Downstream Products

• 142266-63-5 2-chloro-4-methyl-3-pyridinecarboxylic acid 
• 152362-01-1 2-chloro-4-methyl-3-pyridinecarboxamide 
• 133627-45-9 3-Amino-2-chloro-4-methylpyridine 
• 50839-95-7 2-chloro-4-methylnicotinoylchloride 

Relevant articles and documents

2-PHENYLNICOTINIC ACID DERIVATIVE

The present invention is to provide the compounds useful as a treating or preventing agent for gout and hyperuricemia which are 2-phenylnicotinic acid derivatives having a uric acid lowering action due to an excellent xanthine oxidase inhibitory action. Since the 2-phenylnicotinic acid derivatives of the present invention exhibit a uric acid lowering action due to an excellent xanthine oxidase inhibitory action and also hypolipemic action, their utility is very high as a treating or preventive agent for gout and hyperuricemia which are often accompanied by hyperlipemia as a complication.

Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate

A method for making 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate, as depicted in the following reaction scheme.

Regioselective synthesis of 2-chloro 3-pyridinecarboxylates

2-Chlorocyanoacetate was found to undergo base-catalyzed Michael addition to α,β-unsaturated ketones or aldehydes to afford 5-oxopentenenitrile derivatives. In the presence of anhydrous HCl, these compounds cyclize to yield 2-chloro-3-pyridinecarboxylates. The process is highly regiospecific and useful in the synthesis of 2,3-disubstituted pyridines.