660425-16-1

Basic information

• Product Name: 2-Bromo-3,5-difluoropyridine
• Synonyms: 2-Bromo-3,5-Fluoropyridine
• CAS NO: 660425-16-1
• Molecular Formula: C₅H₂BrF₂N
• Molecular Weight: 193.98
• Product Categories: Fluorine series
• Mol File: 660425-16-1.mol

Chemical Properties

• Boiling Point: 36-37°C/0.6mm
• Flash Point: 44.0±25.9℃
• Appearance: /
• Density: 1.808±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -4.05±0.20(Predicted)
• CAS DataBase Reference: 2-Bromo-3,5-difluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3,5-difluoropyridine(660425-16-1)
• EPA Substance Registry System: 2-Bromo-3,5-difluoropyridine(660425-16-1)

Safety Data

• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot
• HazardClass: IRRITANT
• Hazardous Substances Data: 660425-16-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-Bromo-3,5-difluoropyridine is used as a key intermediate in the synthesis of new drugs, contributing to the development of innovative pharmaceuticals with enhanced therapeutic properties.
Used in Agrochemical Research:
In the agrochemical industry, 2-Bromo-3,5-difluoropyridine is utilized as a precursor for the development of novel pesticides, aiming to improve crop protection and yield.
Used in Organic Synthesis:
2-Bromo-3,5-difluoropyridine is employed as a reagent in organic synthesis to introduce fluorine and bromine atoms into organic compounds, which can be valuable for various applications in chemical and pharmaceutical industries.
Overall, 2-Bromo-3,5-difluoropyridine is a valuable and versatile compound that plays a crucial role in the development of new materials and chemicals across different industries.

InChI:InChI=1/C5H2BrF2N/c6-5-4(8)1-3(7)2-9-5/h1-2H

Upstream product

• 76469-41-5 2,3,5‐trifluoropyridine 
• 732306-31-9 3,5-difluoro-2-aminopyridine 
• 851179-06-1 3,5-difluoro-2-hydrazinylpyridine 

Downstream Products

• 425379-31-3 2-(5-bromo-2-fluorophenyl)-3,5-difluoropyridine 
• 425379-32-4 [3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl]boronic acid 
• 660425-43-4 3-chloro-5-[3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl]pyridazine 
• 660425-42-3 5-[3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl]-2H-pyridazin-3-one 
• 660423-96-1 5-[3-(3,5-difluropyridin-2-yl)-4-fluorophenyl]-3-(2-fluorophenyl)pyridazine 
• 884863-46-1 3,5-difluoro-2-(2-fluorophenyl)pyridine 

Relevant articles and documents

DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS

Disclosed are chemical entities of formula (I) wherein X, Y, Z, R1, R3, R4, R5 and R6 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of formula I.

PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I) and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.