851179-06-1

Usage

Uses

Used in Pharmaceutical Synthesis:
3,5-Difluoro-2-hydrazinopyridine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of biologically active compounds.
Used in Agrochemical Development:
In the agrochemical industry, 3,5-Difluoro-2-hydrazinopyridine is utilized as a precursor in the creation of new agrochemicals, potentially enhancing crop protection and yield.
Used in Material Science:
3,5-Difluoro-2-hydrazinopyridine is employed as a component in the development of innovative materials, leveraging its unique structural properties to improve material performance.
Used in Antimicrobial Research:
3,5-Difluoro-2-hydrazinopyridine is used as a subject of study in antimicrobial research due to its demonstrated potential against various microorganisms, offering a new avenue for the development of antimicrobial agents.
Used in Antifungal Applications:
Similarly, in antifungal research, 3,5-Difluoro-2-hydrazinopyridine is explored for its ability to combat fungal infections, making it a valuable asset in the search for new antifungal treatments.

Upstream product

• 76469-41-5 2,3,5‐trifluoropyridine 
• 2875-18-5 2,3,5,6-tetrafluoropyridine 
• 700-16-3 Pentafluoropyridine 
• 851179-05-0 3,5,6-trifluoro-2-hydrazinopyridine 

Downstream Products

• 660425-16-1 2-bromo-3,5-difluoropyridine 
• 67815-54-7 3,4,5-trifluoropyridine 
• 851178-97-7 4-chloro-3,5-difluoro pyridine 

Relevant academic research and scientific papers

Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics

A series of triazolopyridinone derivatives originating from the antidepressant trazodone was designed and pharmacologically evaluated. Most of the compounds with a multireceptor functional profile exhibited high potency at the D2, 5-HT1A, and 5-HT2A receptors. Compounds S1, S3, S9 and S12 were selected for further evaluation of druggable potential. Among these compounds, S1, as a D2 receptor partial agonist, demonstrated very potent inhibition of quipazine-induced head-twitch response, which validated its 5-HT2A receptor antagonistic efficacy in vivo. S1 also demonstrated a dose-dependent effect on PCP-induced hyperactivity when administered orally. Thus, S1 endowed with a triazolopyridinone scaffold represents a valuable lead for the development of novel atypical antipsychotics.

SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS

The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, 5- to 6-membered heteroaryl or phenyl; R2 is hydrogen or alkyl; A is 5-membered heteroaryl; Z is 6- to 10-membered aryl or 5- to 10-membered heteroaryl; all groups being optionally substituted.

A O-carboxamide benzamide derivatives, preparation method thereof and a pesticide (by machine translation)

The present invention provides a kind of formula (I) the structure shown as the O-carboxamide benzamide derivatives. In order to its preparation of insecticide, agricultural, forestry and other common pest with broad-spectrum, high activity, long lasting period and the like, in addition to preventing bollworm, Diamondback moth, Lepidoptera beet pest have very good effect the outer, thereof for the aphid and Homoptera pest also having very good application prospects, therefore in the pest control in the process, can be used as active ingredients used alone, without the need for other insecticides. (by machine translation)

HETEROCYCLIC COMPOUNDS AS PESTICIDES

The present application relates to the use of heterocyclic compounds for controlling animal pests including arthropods, insects and nematodes, to novel heterocyclic compounds, to processes for their preparation and to intermediates for preparing the heterocyclic compounds.

Novel triazolopyridylbenzamides as potent and selective p38α inhibitors

A new class of p38α inhibitors based on a biaryl-triazolopyridine scaffold was investigated. X-ray crystallographic data of the initial lead compound cocrystallised with p38α was crucial in order to uncover a unique binding mode of the inhibitor to the hinge region via a pair of water molecules. Synthesis and SAR was directed towards the improvement of binding affinity, as well as ADME properties for this new class of p38α inhibitors and ultimately afforded compounds showing good in vivo efficacy.

PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I) and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.

NEW 3-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-7-YL)BENZAMIDE DERIVATIVES

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.

Process for preparing 2-aminopyridine derivatives

A method for preparing 2-aminopyridine derivatives, which comprises substituting of fluorine for hydrazine moiety and reducing with hydrogen using 3-substituted-2,5,6-trifluoropyridine as a starting material, provides 2-aminopyridine derivatives having a purity over 98% under a mild reaction condition.

Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution

Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.