The discovery of BMS-275183: An orally efficacious novel taxane
The evolution of 2, a C-4-methylcarbonate analogue of paclitaxel with minimal oral bioavailability and oral efficacy, into its C-3′ -t-butyl-3′-N-t-butyloxycarbonyl analogue (15i), a novel taxane with oral efficacy in preclinical models that is comparable to iv administered paclitaxel, is described.
Mastalerz, Harold,Cook, Donald,Fairchild, Craig R.,Hansel, Steven,Johnson, Walter,Kadow, John F.,Long, Byron H.,Rose, William C.,Tarrant, James,Wu, Mu-Jen,Xue, May Quifen,Zhang, Guifen,Zoeckler, Mary,Vyas, Dolatrai M.
p. 4315 - 4323
(2007/10/03)
More Articles about upstream products of 661489-80-1