661489-80-1Relevant articles and documents
The discovery of BMS-275183: An orally efficacious novel taxane
Mastalerz, Harold,Cook, Donald,Fairchild, Craig R.,Hansel, Steven,Johnson, Walter,Kadow, John F.,Long, Byron H.,Rose, William C.,Tarrant, James,Wu, Mu-Jen,Xue, May Quifen,Zhang, Guifen,Zoeckler, Mary,Vyas, Dolatrai M.
, p. 4315 - 4323 (2007/10/03)
The evolution of 2, a C-4-methylcarbonate analogue of paclitaxel with minimal oral bioavailability and oral efficacy, into its C-3′ -t-butyl-3′-N-t-butyloxycarbonyl analogue (15i), a novel taxane with oral efficacy in preclinical models that is comparable to iv administered paclitaxel, is described.
