Facile and efficient postsynthetic tritium labeling method catalyzed by Pd/C in HTO
We have developed a facile and efficient tritium labeling method using a Pd/C-HTO-H2 system. This method can provide multitritium-labeled compounds in highly diluted HTO under T2 gas-free conditions, and is environmentally benign sin
N6-alkyladenosines and adenines labelled with tritium
Catalytic dehalogenation of 2-chloroadenosine with tritium gas led to tritium labelled adenosine which was subsequently alkylated with (E)-4-t-butoxy-3-methylbut-2-enyl bromide or with 3-methylbut-2-enyl bromide to yield labelled (E)-N6-(4-t-butoxy-3-methylbut-2-enyl)adenosine (2a) and N6-(3-methylbut-2-enyl)adenosine (2b). Acidic hydrolysis of 2b gave N6-(3-methylbut-2-enyl)adenine while acidolysis of a with trifluoroacetic acid led to a mixture of (E)-zeatin riboside and (E)-zeatin. Hydrogenation of (Z/E)-zeatin riboside (3H2, PdO/BaSO4) afforded labelled dihydrozeatin riboside and, after hydrolysis, dihydrozeatin.
Hanus, Jan,Siglerova, Vera,Matucha, Miroslav
p. 523 - 531
(2007/10/03)
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